Abstract: Objective: To investigate the relationship between moderately or severely chronic periodontitis and CHD, and the possible role of AM (including ICAM-1,VCAM-1,P-selectin and E-selectin) in the association between the two diseases. Methods: The subjects were divided into 4 groups according to the diagnostic angiography and periodontal examination.55 cases that originally diagnosed as coronary heart disease were delected, including 24 cases of coronary artery disease along with periodontitis ( Group PD+CHD)，31 cases of coronary heart disease alone (Group CHD);Group PD was made up of 35 patients suffering moderate to advanced periodontitis.Group HC was 39 healthy volunteers.The general information about periodontal status of all the subjects were recorded and blood samples were withdrawed.The level of HDL-C, LDL-C, TC, Triglyceride (TG), ICAM-1, VCAM-1,E-selectin and P-selectin were detected. Results: 1. The study has shown increased incidence of coronary heart disease（OR=2.555, 95%CI:1.096-5.958) in patients with moderate and sever periodontal disease. 2.The differences of ICAM-1,VCAM-1,P-selectin and E-selectin levels among enrolled groups have statistical significance (P<0.05) by ANOVA. The AM levels in moderate or severe periodontitis patients were higher than healthy controls. Conclusion: 1. Periodontal diseases may be a risk factor of CHD. 2. Moderately or severely periodontal infection can influence the AM levels which may in turn affect the initiation and progression of CHD and may be a risk factor for CHD.

Key words: Periodontitis, Coronary heart disease, Adhesion Molecules, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, P-selectin, E-selectin