Abstract: Objective：To observe the preventive and therapeutic effect of medical radiation protective spray (Bergman) on radiation-induced oral mucositis in head and neck tumors.Methods:A retrospective analysis was made of 82 patients with head and neck malignant tumors treated with radiotherapy, 42 of whom were treated with Kangfuxin liquid orally and mouthwash only as control group, and 40 cases were treated with Bergman spraying on oral mucosal surface as experimental group on the basis of control group. Both groups were treated with conventional fractionated intensity modulated radiation therapy. The dose of CTV was 65-70 Gy/36f.Result: Acute oral mucositis occurred in both groups during radiotherapy. 77.5% of the patients in the experimental group were exposed to radiation dose (≥40 Gy), while 69.05% in the control group were exposed to radiation dose （＜40Gy) (P＜0.05); the severity of oral mucositis in the experimental group (incidence of grade 2 and 3 radioactive oral mucositis) was significantly lower than that in the control group (P < 0.01); the body mass of the experimental group before and after radiotherapy was significantly lower than that of the control group (P < 0.01). The degree of weight reduction was significantly lower than that of the control group (P < 0.05).Conclusion: Preventive application of medical radiation protective spray (Bergman) can delay the occurrence of acute radiation oral mucositis, reduce the severity of oral mucositis, reduce the weight loss during radiotherapy, and prevent and treat oral mucositis safely and effectively.

Key words: Head and neck neoplasms, Bergman, Radioactive oral mucositis