Abstract: Bone defect is one of the clinical challenges, which affects the long-term effects on oral implantation. The development of guided bone regeneration technology has solved this problem to a certain extent. The barrier membrane is the basis and key in guiding bone regeneration technology, but due to the limitations and defects of the current membranes, the emergence of a new generation of modified barrier membrane is urgently needed. As a natural peptide involved in the regulation of all bone regeneration processes, growth factors have been confirmed for the regulation of osteogenic cells and osteogenic effects. The growth factors are loaded on the barrier membranes to improve the osteogenesis effect, and the indications of the treatment of bone defects are expanded, which is an important research and development direction of a new generation of barrier membranes. In this paper, the effects of growth factor type, loading mode, release kinetics and osteogenesis effect of barrier membranes combined with growth factors were reviewed, the difficulties and priorities of future barrier membranes combined with growth factors were prospected, and the evidence for further research on bone regeneration was provided.

Key words: growth factor, guided bone regeneration, barrier membrane