双膦酸盐相关性颌骨坏死发病机制的研究进展

Abstract

Abstract: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious adverse reaction caused by long-term use of bisphosphonate in patients. Its main symptoms include soft tissue rupture, bone surface exposure, necrotic area flow pus, focal tooth loosening and so on. Because of the unclear etiological mechanism and lack of corresponding etiological treatment, the current clinical treatment is mainly local dead bone removal and other symptomatic treatment. Scholars have proposed different etiological mechanisms, including imbalance of the bone turnover of the jaw, inhibition of angiogenesis, microbial infection, immune dysfunction, soft tissue toxicity and so on. The recent research progress in the pathogenesis of the disease is reviewed in this paper.

Key words: BRONJ, osteoclast, bone metabolism

CLC Number:

R782.32

References 44

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Research progress of the pathogenesis of bisphosphonate-associated osteonecrosis of the jaw

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