Abstract: Angle Class Ⅱ and Ⅲ malocclusion are complex diseases, and genetic factors play an important role in the etiology of Class Ⅱ and Class Ⅲ malocclusion. At present, domestic and foreign researches focus on the identification of the susceptibility genes of Class Ⅱ and Ⅲ malocclusion using linkage analysis and association analysis. With the development of human genome sequence and high-throughput sequencing technology, genome-wide association analysis has become an efficient molecular genetic method to identify susceptible genes, making it possible to survey the susceptible genes of Class Ⅱ and Class Ⅲ malocclusion at the whole genome level. In this article, research progress of the etiology of genetic factors in Class Ⅱ and Ⅲ malocclusion is reviewed.

Key words: Angle Class II malocclusion, Angle Class III malocclusion, Susceptibility genes, Genome wide association analysis