唾液腺紧密连接蛋白Claudin的研究进展

doi:10.13591/j.cnki.kqyx.2023.02.015

Abstract

Abstract:

Tight junction(TJ) is complex dynamic system involved in protein interactions in the paracellular secretory pathway, with both barrier and fence functions. Claudin family, the main section of tight junction strands, will be abnormal in expression pattern in the circumstances of radiation injuries, inflammation, Sj?gren's syndrome, diabetes and other pathological conditions in salivary glands. This change leads to abnormal structure and function of tight junctions, indirectly manifested as salivary gland dysfunction. In addition, the difference of Claudin expression in salivary gland tumors can also be used as an indicator of tumor type and prognosis. This review focuses on the progress of research on common Claudin in salivary glands, including the structure, function, expression patterns of related diseases and their applications. It is believed that the review may provide new ideas for clinical and basic research on Claudin protein-related diseases.

Key words: tight junction, Claudin, salivary glands, expression pattern, abnormal change

CLC Number:

R781.7

ZHANG Pengxin, FEI Runxin, XU Hui. Research progress of tight junction protein Claudin of salivary glands[J]. Stomatology, 2023, 43(2): 176-181.

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Research progress of tight junction protein Claudin of salivary glands

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