Abstract: Objective To evaluate the quality of life (QOL) of patients with burning mouth syndrome and to preliminarily analyze factors impacting the QOL of burning mouth syndrome patients. Methods The QOL of burning mouth syndrome patients (n = 45) and a control group (n = 43) was assessed by two questionnaires: WHOQOL-BREF and OHIP-14. All data were analyzed by SPSS18.0 software package. Results WHOQOL - BREF questionnaire showed that in the psychological field, scores of patients with burning mouth syndrome were significantly lower than those of the healthy control group, and there were statistically significant differences (10.62±1.88 vs 12.12±1.79，p<0.05); OHIP - 14 questionnaire showed that scores of patients with burning mouth syndrome were higher than those of the healthy control group in psychological discomfort (56.65±8.14 vs 31.55±13.87) and physical pain (59.26±9.58 vs 30.85±14.62), and there were statistically significant differences (p < 0.005). Conclusion: Burning mouth syndrome has significant influence on the quality of life of patients. We must pay attention to the psychological factors clinically, and carry out appropriate psychological counseling, even necessary psychological treatment.