Abstract: Objective To explore clinical features and therapeutic method of periodontal-endodontic-combined lesions, and provide basis for reasonable clinical treatment.Methods Analyze 165 cases with 183 teeth which had periodontal-endodontic-combined lesions, and give corresponding treatment according to the condition of the teeth. Observe clinical efficacy after one year’s follow-up. Results All the 165 cases of periodontal-endodontic-combined lesions with 183 teeth treated were followed up one year after treatment, with 112 teeth markedly effective, 42 improved, and 29 ineffective. The total effective rate was 84.15%. In the 52 teeth whose pulp periapical disease led to the periodontal lesions, 39 were markedly effective and 9 were improved. The effective rate was 92.31%. In the 85 teeth whose periodontal lesions led to pulp disease, 49 were markedly effective and 23 were improved. The effective rate was 84.71%. In the 46 teeth whose periodontal lesions coexisted with pulp disease, 24 were markedly effective, and 10 were improved. The effective rate was 73.91%. Conclusions For treatment of periodontal-endodontic-combined lesions, doctors should take different treatment methods for different types, and take many factors into consideration. Thereinto, comprehensive examination, correct diagnosis, proper treatment and patient compliance all play vital role in a successful treatment.fasdf