Abstract: Objective To investigate the stress on maxillary dentition and its periodontal tissue under various anchorage conditions. Methods Use the constructed three-dimensional models of the maxillary dentition, periodontal membrane, alveolar bone and MBT straight wire appliance into ANSYS software, simulate the sliding method for closing the space of exodontias, and investigate the stress condition and displacement of teeth and periodontal tissue under various anchorage conditions. Results Making second maxillary molar as anchorage tooth can decrease nearly two thirds displacement of the first maxillary molar, and microscrew implant can decrease the displacement of the first maxillary molar obviously. Conclusion We can chose appropriate anchorage system for different patients.