›› 2015, Vol. 35 ›› Issue (4): 258-261.

• Basic Research • Previous Articles     Next Articles

Expression of MMP9 and VEGF in parotid gland pleomorphic adenoma

  

  • Received:2014-09-05 Revised:2014-12-03 Online:2015-04-28 Published:2015-04-27
  • Contact: Han-fei CHENG E-mail:173179664@qq.com

Abstract: Objective To investigate the relationship between the expressions of MMP9 and VEGF in parotid pleomorphic adenoma,benign pleomorphic adenoma and malignant pleomorphic adenoma.Methods   Realtime fluorescent quantitative PCR and Western Blotting methods were used to detect the expression of MMP9 and VEGF in 32 pairs of pleomorphic adenoma tissue and the tissue beside the tumor.Results  26 out of 32 cases were benign pleomorphic adenoma,and other 6 were malignant.The mRNA and protein expression rate of MMP9 and VEGF in pleomorphic adenoma tissues were higher than those in the tissue beside the tumor(P<0.05).The mRNA and protein expression rate of MMP9 and VEGF in malignant pleomorphic adenoma tissues were higher than those in benign pleomorphic adenoma tissues(P<0.05).Conclusions   MMP9 and VEGF are highly expressed in parotid pleomorphic adenoma,and MMP9 and VEGF may be related with malignant pleomorphic adenoma.Taking 1.0 cm away from parotid pleomorphic adenoma as a boundary is safe for the excision of parotid pleomorphic adenoma.

Key words: pleomorphic adenoma, MMP9, VEGF

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