›› 2015, Vol. 35 ›› Issue (4): 314-317.

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Advance in the research of hepcidin and its role in bone metabolism

  

  • Received:2014-11-27 Revised:2014-12-23 Online:2015-04-28 Published:2015-04-27

Abstract: Hepcidin is a kind of antimicrobial peptide regulating organic iron homeostasis,and it is encoded by HAMP gene.Concerning the generating mechanism of hepcidin,the content of serum iron,bone morphogenetic proteins(BMPs),interleukin6(IL6),hypoxiainducible factor(HIF)or other signaling factors can regulate its expression.The latest study indicates that hepcidin is involved in bone metabolism.It affects bone metabolism process through the “hepcidiniron metabolism bone metabolism”and “JAK/STAT”signaling pathway.This articlereviews relevant researchesofhepcidin generation mechanism and its relationship with bonemetabolism .

Key words: hepcidin, bone metabolism, bone morphogenetic proteins, “JAK/STAT”signaling pathway

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