Abstract:

Bone is an important organ of the human body, with a variety of functions such as support and protection, and the internal bone marrow tissue is the main hematopoietic site. Hematopoiesis and bone homeostasis maintenance are important physiological processes in the bone, which are regulated by a variety of factors, and its destruction will lead to hematopoietic dysfunction, osteoporosis and other diseases. Blood vessels are widely distributed in the bone and, in addition to being ducts for oxygen, nutrients and waste, also play an important role in a variety of physiological and pathological processes within the bone. Studies in recent years have found that bone blood vessels have different subtypes with distinct distribution and properties which form specific vascular microenvironment. The bone vascular microenvironment is composed of a variety of cells and their secreted signaling molecules, such as endothelial cells, which are involved in regulating bone marrow hematopoiesis and bone homeostasis maintenance in a variety of ways. In this paper, the distribution and typing of bone blood vessels, the composition of bone blood vessel microenvironment, and the regulation of hematopoiesis and bone homeostasis by bone blood vessels and their microenvironment are reviewed, in order to deepen the understanding of bone blood vessels and their microenvironment, and provide insights for the treatment of related diseases.

Key words: bone blood vessel, type H blood vessel, osteovascular microenvironment, hematopoiesis, bone homeostasis