›› 2021, Vol. 41 ›› Issue (7): 640-643.

• 综述 • 上一篇    下一篇

口腔微生物致宿主表观遗传改变的研究进展

时小婷,潘亚萍   

  1. 中国医科大学附属口腔医院
  • 收稿日期:2020-09-24 修回日期:2020-11-19 出版日期:2021-07-28 发布日期:2021-07-28
  • 通讯作者: 潘亚萍 E-mail:yppan@cmu.edu.cn
  • 基金资助:
    牙龈卟啉单胞菌通过STAT1,3/FLI1/KRT途径调节口腔上皮细胞增殖和异常分化的作用机制研究

Advances in epigenetic changes in hosts caused by oral microbes

Xiao-Ting SHI1,   

  • Received:2020-09-24 Revised:2020-11-19 Online:2021-07-28 Published:2021-07-28

摘要: 微生物在感染宿主的过程中能够调控宿主的生理功能,其中一种重要的调控方式是表观遗传调控。表观遗传是指在基因DNA序列不发生改变的情况下, 基因的表达和功能发生稳定改变,并产生可遗传的表型。表观遗传调控在微生物引起宿主免疫反应的过程中起到重要作用。明确微生物对宿主的表观遗传调控机制有利于开展临床靶向治疗,加强表观遗传调节剂的临床应用,为相关疾病防治提供新的策略。该文对几种口腔常见微生物引起的宿主表观遗传改变及相关机制作一综述。

关键词: 口腔微生物, 表观遗传学, 甲基化, 乙酰化

Abstract: Microbes can regulate the physiological function of infected hosts during hostmicrobe interaction. One of the important regulations is epigenetic regulation. Epigenetic inheritance relates to changes in gene expression and function that are not encoded in the DNA sequences and inducible heritable phenotypes. The epigenetic regulation plays an essential role in host immune response caused by microbe challenges. Clarifying the epigenetic regulation mechanisms of microbes in the host is beneficial to carry out clinical targeted therapies, enhance the clinical application of epigenetic regulators and provide new strategies for the prevention and treatment of related diseases. This review summarizes the epigenetic changes in hosts caused by several common oral microbes and related mechanisms.

Key words: oral microbe, epigenetics, methylation, acetylation

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