唾液外泌体在口腔鳞状细胞癌的研究进展

doi:10.13591/j.cnki.kqyx.2022.07.018

摘要/Abstract

摘要： 口腔鳞状细胞癌 (oral squamous cell carcinoma,OSCC)是影响人类健康的主要恶性肿瘤之一。由于缺少早期筛查及检测的肿瘤生物标记物,导致晚期口腔癌的致死率达到50%。外泌体(exosomes)是细胞释放到细胞外的纳米级囊泡,广泛分布于唾液中,携带生物活性分子,介导肿瘤细胞和肿瘤微环境之间的相互作用。随着对外泌体研究的深入,发现外泌体与口腔疾病的诊断和治疗有着密切的关系,可作为口腔癌早期筛查的理想标志物。本文就唾液中外泌体在口腔鳞状细胞癌的研究进展作一综述,为口腔癌早期诊断的研究提供参考。

关键词: 唾液, 生物标志物, 外泌体, 口腔癌

Abstract: Oral squamous cell carcinoma (OSCC) is one of the major malignant tumors affecting human health. Due to the lack of biomarkers for early detection and risk assessment, more than 50% patients are often diagnosed at the late stage. Exosomes are nano-sized vesicles secreted and released by cells to the outside,which are widely present in the saliva. Exosomes carry various bioactive substances and mediate the interaction between tumor cells and tumor microenvironment. With the development of exosomes research, scientists found that exosomes are closely related to the diagnosis and treatment of oral diseases. And exosomes can be used as ideal oral disease biomarkers for early diagnosis. This articles reviews the research development of salivary exosomes in Oral squamous cell carcinoma,in order to provide the reference for studies on early diagnosis of oral carcinoma.

Key words: saliva, biomarkers, exosomes, oral cancer

中图分类号:

R780.2/R739.8

徐英娇, 王姗. 唾液外泌体在口腔鳞状细胞癌的研究进展[J]. 口腔医学, 2022, 42(7): 664-667.

XU Yingjiao, WANG Shan. Research progress on the role of salivary exosomes in oral squamous cell carcinoma[J]. Stomatology, 2022, 42(7): 664-667.

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