Abstract: Objective To evaluate the recent treatment response and long-term clinical effect of root canal filling with iRoot SP sealer and compare it with root canal filling with Cortisomol. Method 120 teeth suffered from chronic pulpitis or periapcial periodontitis were randomly divided into 2 groups, and filled respectively by iRoot SP or Cortisomol sealer combined with cold gutta-percha. The occurrence of pain in 7 days after treatment was recorded and the therapeutic effects were evaluated in the following 3 months and 2 years. Results The occurrence rate of pain after root canal therapy in 7 days using iRoot SP and Cortisomol were both low (P>0.05). There was no statistical significance in success rate between iRoot SP and Cortisomol after 3 months (94.83% vs. 96.67%)(P>0.05). The success rate of treatment with iRoot SP (93.10%) after 2 years was significantly higher than that with Cortisomol sealer (80.70%) in root canal filling (P<0.05). Conclusion Both the treatment with iRoot SP sealer in root canal filling and with Cortisomol sealer can significantly reduce the postoperative pain. However, iRoot SP sealer shows better clinical treatment effects than Cortisomol in the long run and the former is worth the widespread in clinical application.

Key words: Root SP, Cortisomol, the pain after treatment, the effects of root canal filling