高原地区牙周炎患者血清内脂素和瘦素水平的检测分析

doi:10.13591/j.cnki.kqyx.2022.01.010

摘要/Abstract

摘要： 目的检测青海西宁地区牙周炎患者血清中内脂素(visfatin,VF)与瘦素(leptin,LP)的表达水平及其与牙周炎症指标的相关性。方法随机选取2019年3—12月就诊的牙周炎患者50例(牙周炎组)和牙周健康者50例(健康对照组),由同一临床医师测量牙周炎症临床指标,包括探诊深度(probing depth,PD)、临床附着丧失(clinical attachment loss,CAL)、牙龈指数(gingival index,GI)和龈沟出血指数(sulcular bleeding index,SBI),同时采集血液样本,采用酶联免疫吸附测定(enzyme linked immunosorbent assay,ELISA)方法检测血清VF和LP的表达水平。结果与健康对照组相比,牙周炎组血清VF水平较高,血清LP水平较低,差异具有统计学意义(P<0.01)。牙周炎患者血清VF水平与PD(r=0.97,P<0.01)、CAL(r=0.94,P<0.01)呈正相关,血清LP水平与PD(r=-0.86,P<0.01)、CAL(r=-0.88,P<0.01)呈负相关,VF、LP均与GI、SBI无相关性(P>0.05)。结论在高原地区牙周炎患者中,血清VF和LP水平与牙周炎发生发展密切相关,在一定程度上可反映牙周组织的破坏程度。

关键词: 高原地区, 内脂素, 瘦素, 牙周炎

Abstract: Objective To evaluate serum visfatin and leptin levels in patients with periodontitis living in Xining, Qinghai Province and to explore associations between serum visfatin and leptin levels and periodontal indexes. Methods Fifty patients with periodontitis (periodontitis group) and 50 healthy periodontal patients (healthy control group) were randomly selected from from March 2019 to December 2019. Demographic and clinical data including probing depth (PD), clinical attachment loss (CAL), gingival index (GI), sulcular bleeding index (SBI) were obtained by the same senior periodontist. Serum visfatin and leptin levels were measured by enzyme linked immunosorbent assay (ELISA) technique. Results Compared with the healthy control group, the level of serum VF was higher and the level of serum LP was lower in the periodontitis group (P<0.01), and these differences were statistically significant. The level of serum VF was positively correlated with PD (r=0.97, P<0.01) and CAL(r=0.94, P<0.01). The level of serum LP was negatively correlated with PD (r=-0.86, P<0.01) and CAL (r=-0.88, P<0.01). VF and LP were not correlated with GI and SBI (P>0.05). Conclusion In periodontitis patients living in plateau section, the level of serum VF and LP is closely related to the occurrence and development of periodontitis, which can reflect the degree of periodontal tissue damage to a certain extent.

Key words: plateau section, visfatin, leptin, periodontitis

中图分类号:

R781.4

李燕, 张羽涛, 刘倩雯, 马媛, 李富花, 赵星星. 高原地区牙周炎患者血清内脂素和瘦素水平的检测分析[J]. 口腔医学, 2022, 42(1): 58-61.

LI Yan, ZHANG Yutao, LIU Qianwen, MA Yuan, LI Fuhua, ZHAO Xingxing. Serum visfatin and liptin levels and their associations with periodontal indexes in patients with periodontitis in plateau section[J]. Stomatology, 2022, 42(1): 58-61.

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