Caspase家族参与乳牙根吸收牙髓组织细胞凋亡的研究进展

doi:10.13591/j.cnki.kqyx.2022.02.017

摘要/Abstract

摘要： 在乳恒牙替换过程中,乳牙牙髓组织逐渐减少,这与牙髓组织发生细胞凋亡有关。天冬氨酸特异性蛋白水解酶(cysteine-containing aspartate-specific protease,Caspase)在细胞凋亡中发挥重要作用。该文就乳牙生理性根吸收过程中牙髓组织的细胞凋亡情况及Caspase家族在其中发挥的作用作一综述。

关键词: 乳牙, 细胞凋亡, Caspase

Abstract: During the process of permanent teeth replacing primary teeth, the pulp tissue of deciduous teeth gradually decreases, which relates to the apoptosis of dental pulp tissue. Cysteine-containing aspartate-specific protease (Caspase) plays an important role in cell apoptosis. This article summarizes the apoptosis of dental pulp tissue and the role played by Caspase family in the process of physiological root resorption of deciduous teeth.

Key words: deciduous teeth, apoptosis, Caspase

中图分类号:

R349.54

林珊如, 钱虹, 吕婧雯, 萧曼雪. Caspase家族参与乳牙根吸收牙髓组织细胞凋亡的研究进展[J]. 口腔医学, 2022, 42(2): 180-183.

LIN Shanru, QIAN Hong, LYU Jingwen, XIAO Manxue. Research progress of Caspase family involved in cell apoptosis of dental pulp during the root absorption of deciduous teeth[J]. Stomatology, 2022, 42(2): 180-183.

参考文献

[1] Harokopakis-Hajishengallis E. Physiologic root resorption in primary teeth: Molecular and histological events[J]. J Oral Sci, 2007, 49(1):1-12.
[2] Sahara N. Cellular events at the onset of physiological root resorption in rabbit deciduous teeth[J].Anat Rec, 2001, 264(4):387-396.
[3] Xu X, Lai Y, Hua ZC. Apoptosis and apoptotic body: Disease message and therapeutic target potentials[J]. Biosci Rep, 2019, 39(1):BSR20180992.
[4] Chen HX, Zhang JJ, Gao YM, et al. Sensitive cell apoptosis assay based on caspase-3 activity detection with graphene oxide-assisted electrochemical signal amplification[J]. Biosens Bioelectron, 2015, 68: 777-782.
[5] Baker A,Karpagaselvi K, Kumaraswamy J, et al. Role of dental pulp in age estimation: A quantitative and morphometric study[J]. J Forensic Dent Sci, 2019, 11(2):95-102.
[6] Yu C, Abbott P. An overview of the dental pulp:Its functions and responses to injury[J]. Aust Dent J, 2007, 52: S4-S6.
[7] Zhu Y, Shang LJ, Chen XY, et al. Deciduous dental pulp stem cells are involved in osteoclastogenesis during physiologic root resorption[J]. J Cell Physiol, 2013, 228(1):207-215.
[8] Eronat C, Eronat N, Aktug M. Histological investigation of physiologically resorbing primary teeth using Ag-NOR staining method[J].Int J Paediatr Dent, 2002,12(3):207-214.
[9] Rajan S, Day PF, Christmas C, et al. Pulpal status of human primary molars with coexisting caries and physiological root resorption[J]. Int J Paediatr Dent, 2014, 24(4):268-276.
[10] 王宇琛,王辰,徐璐璐.调控乳牙生理性根吸收的细胞及分子机制的研究进展[J].临床口腔医学杂志, 2017,33(10):630-632.
[11] Monteiro J, Day P, Duggal M, et al. Pulpal status of human primary teeth with physiological root resorption[J]. Int J Paediatr Dent, 2009,19(1):16-25.
[12] Rodrigues LV, Del Puerto HL, Brant JM, et al. Caspase-3/caspase-8, bax and bcl2 in pulps of human primary teeth with physiological root resorption[J]. Int J Paediatr Dent, 2012, 22(1):52-59.
[13] Bardellini E, Amadori F, Santoro A, et al. Odontoblastic cell quantification and apoptosis within pulp of deciduous teeth versus pulp of permanent teeth[J]. J Clin Pediatr Dent, 2016, 40(6):450-455.
[14] van Opdenbosch N, Lamkanfi M. Caspases in cell death, inflammation, and disease[J]. Immunity, 2019, 50(6):1352-1364.
[15] Majtnerová P, Rousar T. An overview of apoptosis assays detecting DNA fragmentation[J]. Mol Biol Rep, 2018, 45(5):1469-1478.
[16] Rodrigues LV, Vasconcelos AC, Campos PA, et al. Apoptosis in pulp elimination during physiological root resorption in human primary teeth[J]. Braz Dent J, 2009, 20(3):179-185.
[17] Loo DT. In situ detection of apoptosis by the TUNEL assay: an overview of techniques[J]. Methods Mol Biol, 2011,682:3-13
[18] Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics[J]. Br J Cancer, 1972, 26(4):239-257.
[19] Kesavardhana S, Malireddi RKS, Kanneganti TD. Caspases in cell death, inflammation, and pyroptosis[J]. Annu Rev Immunol, 2020, 38(1):567-595.
[20] Qian H, Huang Q, Chen YX, et al. Caspase-9 was involved in cell apoptosis in human dental pulp stem cells from deciduous teeth[J]. Mol Med Rep, 2018, 18(1):1067-1073.
[21] Ramirez MLG, Salvesen GS. A primer on caspase mechanisms[J]. Semin Cell Dev Biol, 2018, 82: 79-85.
[22] Man SM, Kanneganti TD. Converging roles of caspases in inflammasome activation, cell death and innate immunity[J]. Nat Rev Immunol, 2016, 16(1):7-21.
[23] D'Arcy MS. Cell death: A review of the major forms of apoptosis, necrosis and autophagy[J]. Cell Biol Int, 2019, 43(6):582-592.
[24] Kale J, Osterlund EJ, Andrews DW. BCL-2 family proteins: Changing partners in the dance towards death[J]. Cell Death Differ, 2018, 25(1):65-80.
[25] Kalkavan H, Green DR. MOMP, cell suicide as a BCL-2 family business[J]. Cell Death Differ, 2018, 25(1):46-55.
[26] Shalini S, Dorstyn L, Dawar S, et al. Old, new and emerging functions of caspases[J]. Cell Death Differ, 2015, 22(4):526-539.
[27] Choudhary GS, Al-Harbi S, Almasan A. Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis[J]. Methods Mol Biol, 2015, 1219: 1-9.
[28] Fan TJ, Han LH, Cong RS, et al. Caspase family proteases and apoptosis[J]. Acta Biochim et Biophys Sin, 2005, 37(11):719-727.
[29] Peña-Blanco A, García-Sáez AJ. Bax, Bak and beyond-mitochondrial performance in apoptosis[J]. Febs J, 2018, 285(3):416-431.
[30] Wnęk A, Andrzejewska E, Kobos J, et al. Molecular and immunohistochemical expression of apoptotic proteins Bax, Bcl-2 and Caspase 3 in infantile hemangioma tissues as an effect of propranolol treatment[J]. Immunol Lett, 2017, 185: 27-31.
[31] 赵辛,杨宽,王子瑞,等.根吸收不同时期乳牙牙周膜干细胞通过NK细胞进行免疫调节作用的研究[J]. 口腔医学, 2020,40(6):517-520.
[32] 谢伟鸿,余东升,赵玮.非综合征型先天缺牙致病基因和分子机制的研究进展[J]. 口腔疾病防治, 2020,28(4):257-261.
[33] 林曦, 郑相淮, 徐淑兰. 儿童及青少年的牙种植进展[J]. 口腔疾病防治, 2020, 28(11):728-732.