骨血管及其微环境调控造血和骨稳态的研究进展

doi:10.13591/j.cnki.kqyx.2023.08.013

摘要/Abstract

摘要：

造血和骨稳态维持是骨内重要的生理过程,受多种因素调控,其被破坏将导致造血功能障碍、骨质疏松等多种疾病。血管在骨中广泛分布,除了作为运送氧气、营养物质和废物的管道外,还在骨内多种生理病理过程中发挥重要作用。近年来研究发现,骨血管具有不同亚型,其分布和性质各不相同,并形成了特异的血管微环境。骨血管微环境由内皮细胞在内的多种细胞及其分泌的信号分子组成,通过多种方式参与调控骨髓造血和骨稳态维持。本文对骨血管的分布和分型、骨血管微环境的组成以及骨血管及其微环境对造血和骨稳态的调控进行综述,以期加深对骨血管及其微环境的认识,为相关疾病的治疗提供新的思路。

关键词: 骨血管, H型血管, 骨血管微环境, 造血, 骨稳态

Abstract:

Bone is an important organ of the human body, with a variety of functions such as support and protection, and the internal bone marrow tissue is the main hematopoietic site. Hematopoiesis and bone homeostasis maintenance are important physiological processes in the bone, which are regulated by a variety of factors, and its destruction will lead to hematopoietic dysfunction, osteoporosis and other diseases. Blood vessels are widely distributed in the bone and, in addition to being ducts for oxygen, nutrients and waste, also play an important role in a variety of physiological and pathological processes within the bone. Studies in recent years have found that bone blood vessels have different subtypes with distinct distribution and properties which form specific vascular microenvironment. The bone vascular microenvironment is composed of a variety of cells and their secreted signaling molecules, such as endothelial cells, which are involved in regulating bone marrow hematopoiesis and bone homeostasis maintenance in a variety of ways. In this paper, the distribution and typing of bone blood vessels, the composition of bone blood vessel microenvironment, and the regulation of hematopoiesis and bone homeostasis by bone blood vessels and their microenvironment are reviewed, in order to deepen the understanding of bone blood vessels and their microenvironment, and provide insights for the treatment of related diseases.

Key words: bone blood vessel, type H blood vessel, osteovascular microenvironment, hematopoiesis, bone homeostasis

中图分类号:

R336

田炯义, 陈芊凝, 陈骥, 郑晨曦. 骨血管及其微环境调控造血和骨稳态的研究进展[J]. 口腔医学, 2023, 43(8): 736-741.

TIAN Jiongyi, CHEN Qianning, CHEN Ji, ZHENG Chenxi. Research progress of bone blood vessels and their microenvironment in regulating hematopoiesis and bone homeostasis[J]. Stomatology, 2023, 43(8): 736-741.

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