牙龈间充质干细胞治疗口腔疾病研究进展

doi:10.13591/j.cnki.kqyx.2024.07.013

摘要/Abstract

摘要：

牙龈间充质干细胞(gingival mesenchymal stem cells,GMSCs)是存在于牙龈组织固有层内的一群间充质干细胞,它不仅可以从健康的牙龈组织中分离出来,还可以从增生性甚至炎性牙龈组织中分离出来。GMSCs因来源丰富,易于获取,且具有独特的免疫调节特性及多向分化潜能,成为口腔疾病治疗的研究热点。目前已被应用于牙周炎、牙龈萎缩、口腔癌、颌骨缺损、神经修复等口腔疾病的治疗中,该文对近年来GMSCs在口腔疾病中相关应用的研究进展作一综述。

关键词: 牙龈间充质干细胞, 组织工程, 再生医学

Abstract:

Gingival mesenchymal stem cells(GMSCs)are a population of mesenchymal stem cells found in the lamina propria of gingival tissue and can be isolated not only from healthy gingival tissue but also from hyperplastic or even inflamed gingival tissue. GMSCs have become a hot topic of research in oral disease treatment because of their abundant sources, easy availability, unique immunomodulatory properties and multi-directional differentiation potential. GMSCs have been used in the treatment of periodontitis, gingival recession, oral cancer, mandibular defects, peripheral nerve injury repair and so on. To prevent and treat oral diseases, this study will review the recent progress of research on the application of GMSCs in oral diseases.

Key words: gingival mesenchymal stem cells, tissue engineering, regenerative medicine

中图分类号:

R349.5

赵彩桃, 谢小美, 尹文, 陈蕊, 范桢, 郝春波. 牙龈间充质干细胞治疗口腔疾病研究进展[J]. 口腔医学, 2024, 44(7): 556-560.

ZHAO Caitao, XIE Xiaomei, YIN Wen, CHEN Rui, FAN Zhen, HAO Chunbo. Research and application progress of gingival mesenchymal stem cells in oral diseases[J]. Stomatology, 2024, 44(7): 556-560.

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