牙周炎与炎症性肠病相关性研究的Meta分析

›› 2021, Vol. 41 ›› Issue (11): 1011-1015.

牙周炎与炎症性肠病相关性研究的Meta分析

吕宗凯¹,郑杨灿²,杜胜男¹,谢永林³

1. 南充市中心医院口腔科
2. 南充市中心医院泌尿外科
3. 南充市中心医院

收稿日期:2020-09-15 修回日期:2020-11-03 出版日期:2021-11-28 发布日期:2021-11-29
通讯作者: 郑杨灿 E-mail:814386325@qq.com
基金资助:
四川省基层卫生事业发展研究中心课题

Association between periodontitis and inflammatory bowel diseases：A Meta analysis

Received:2020-09-15 Revised:2020-11-03 Online:2021-11-28 Published:2021-11-29

摘要/Abstract

摘要： 目的探究牙周炎与炎症性肠病之间的相关性。方法电子检索Medline、Pubmed、EMBASE、CBM、CNKI和维普等中英文期刊数据库并手工检索相关期刊，收集有关牙周炎与炎症性肠病相关性研究的文献。通过文献筛选和数据提取后采用Revman5.3.3进行Meta分析。结果最终纳入9篇英文文献，纳入研究对象35 129名，其中炎症性肠病患者7 676名。Meta分析结果显示炎症性肠病（OR=1.66，Z=13.21，P<0.000 01），克罗恩病（OR=1.60，Z=11.92，P<0.000 01）和溃疡性结肠炎（OR=3.33，Z=7.58，P<0.000 01）患者的牙周炎患病率均明显高于对照组。结论牙周炎与克罗恩病和溃疡性结肠炎等炎症性肠病之间具有显著的相关性。

关键词: 牙周炎, 炎症性肠病, 循证医学 , Meta分析

Abstract: Objective To explore the association between periodontitis and inflammatory bowel diseases. Methods Chinese and English journal databases such as Medline, Pubmed, EMBASE, CBM, CNKI and VIP were searched electronically and examined by hand. The literatures on the association between periodontitis and inflammatory bowel diseases were collected through systematic literature screening and data extraction. Metaanalysis was performed by Revman 5.3.3. Results Nine English trials met the inclusion criteria, including 35 129 participants, 7 676 of whom with inflammatory bowel diseases. The result of Metaanalysis showed that patients with inflammatory bowel diseases（OR=1.66，Z=13.21，P<0.000 01）, Crohn's disease（OR=1.60，Z=11.92，P<0.000 01）or ulcerative colitis（OR=3.33，Z=7.58，P<0.000 01） were more likely to develop chronic periodontitis. Conclusion There is a significant correlation between periodontitis and inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.

Key words: periodontitis, inflammatory bowel disease, evidence- based medicine, Meta-analysis

中图分类号:

R781.42

吕宗凯郑杨灿杜胜男谢永林. 牙周炎与炎症性肠病相关性研究的Meta分析[J]. 口腔医学, 2021, 41(11): 1011-1015.

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