小分子化合物延缓间充质干细胞衰老的研究进展

doi:10.13591/j.cnki.kqyx.2022.03.015

摘要/Abstract

摘要： 多种诱因造成的细胞衰老制约了间充质干细胞(mesenchymal stem cells,MSCs)在口腔组织再生中的应用,然而部分小分子化合物能延缓MSCs衰老、增强干细胞特性。该文对衰老MSCs的特征进行概括,并对热点小分子化合物发挥作用的可能治疗靶点、机制予以综述,为促进未来口腔再生医学的发展补充一定的理论依据。

关键词: 间充质干细胞, 小分子化合物, 细胞衰老, 治疗靶点

Abstract: Cell senescence caused by various factors restricts the application of mesenchymal stem cells (MSCs) in oral tissue regeneration. However, part of small molecule compounds could delay the senescence of MSCs and extend characteristics of stem cells. This article introduces features of senescent MSCs, and summarizes possible therapeutic targets together with mechanisms of hotspot small molecule compounds, so as to supplement certain theoretical basis for promoting the future development of oral regenerative medicine.

Key words: mesenchymal stem cell, small molecule compound, cell senescence, therapeutic target

中图分类号:

R349.53

冯笑梅, 郝兴瑶, 文勇. 小分子化合物延缓间充质干细胞衰老的研究进展[J]. 口腔医学, 2022, 42(3): 266-270.

FENG Xiaomei, HAO Xingyao, WEN Yong. Advance of research on small molecule compounds delaying senescence of mesenchymal stem cells[J]. Stomatology, 2022, 42(3): 266-270.

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