牙囊在牙萌出骨重塑的调控作用及机制研究进展

doi:10.13591/j.cnki.kqyx.2023.08.016

摘要/Abstract

摘要：

牙萌出是一个复杂的生理过程,涉及牙槽骨的吸收和形成。研究表明,牙囊通过调节牙齿周围骨组织重塑,在牙萌出中发挥关键作用。牙囊分泌多种趋化因子招募单核细胞,并通过RANKL/RANK/OPG轴促进破骨细胞分化成熟,导致冠方骨质吸收形成萌出道;同时牙囊内富含具有成骨分化潜能的牙囊细胞,在TGF-β/BMP和Wnt等信号通路以及表观遗传的调控下诱导根方牙槽骨形成,为萌出提供动力。近年来,有关牙萌出骨重塑机制研究取得了新进展,本文就牙萌出过程中牙囊参与调控骨重塑的细胞及分子机制作一综述。

关键词: 牙囊, 牙萌出, 骨重塑, 破骨细胞, 成骨分化

Abstract:

Tooth eruption undergoes a series of sophisticated physiological procedures that involve the formation and resorption of alveolar bone. Previous studies indicated that dental follicle(DF) plays a key role in tooth eruption by modulating bone remodeling around the tooth. It secretes multiple chemokines to recruit monocytes and facilitate the differentiation and maturation of osteoclasts via RANKL/RANK/OPG axis, eventually leading to the resorption of the coronal alveolar bone to form eruptive pathway. Simultaneously, dental follicle is enriched with dental follicle cells, whose osteogenic activity are subject to TGF-β/BMP and WNT signaling pathway as well as epigenetic regulation, which in turn promotes the formation of basal alveolar bone and provides motive force for tooth eruption. In recent years, studieson bone remodeling mechanisms of tooth eruption have made further progress, and this review elaborates the cellular and molecular mechanisms involved in bone remodeling by dental follicle during tooth eruption.

Key words: dental follicle, tooth eruption, bone remodeling, osteoclast, osteogenic differentiation

中图分类号:

R781

姜震, 韩雪, 蒋备战. 牙囊在牙萌出骨重塑的调控作用及机制研究进展[J]. 口腔医学, 2023, 43(8): 752-756.

JIANG Zhen, HAN Xue, JIANG Beizhan. Research progress of the regulatory mechanisms of dental follicle in bone remodeling during tooth eruption[J]. Stomatology, 2023, 43(8): 752-756.

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