光生物调节疗法治疗放射性口腔黏膜炎作用机制研究进展

doi:10.13591/j.cnki.kqyx.2023.12.015

摘要/Abstract

摘要：

光生物调节疗法(photobiomodulation therapy,PBMT)是一种利用光子能量影响生物代谢的治疗方法。其作为一种无创性非药物治疗手段,具有缓解疼痛,控制炎症及促进组织修复的作用。近年来,PBMT在口腔疾病方面应用的研究日益增加。放射性口腔黏膜炎(radiation-induced oral mucositis,RTOM)作为头颈部恶性肿瘤放疗后常见并发症之一,发病率为80%~100%。RTOM 临床表现主要为口腔灼痛、溃疡,损伤达黏膜下层引起剧烈疼痛,影响患者饮水进食。11%的患者因不能耐受RTOM而中断放疗。有相关临床试验报道PBMT对缓解RTOM疼痛,促进组织愈合具有一定的疗效。该文就PBMT在RTOM治疗中作用的机制进行综述。

关键词: 光生物调节疗法, 放射性口腔黏膜炎, 机制

Abstract:

Photobiomodulation therapy(PBMT) is a therapeutic method that uses photon energy to affect biological metabolism. As a non-invasive non-drug therapy, it can relieve pain, control inflammation and promote tissue repair. In recent years, the research on the application of PBMT in oral diseases is increasing. Radiation-induced oral mucositis(RTOM) is one of the common complications after radiotherapy for head and neck cancer, with an incidence of 80%-100%. The main clinical manifestations of RTOM are burning pain and ulceration in the mouth, which can lead to severe pain in the submucosa and affect patients’ drinking and eating. Radiotherapy was interrupted in 11% of patients because they could not tolerate RTOM. Related clinical trials have reported that PBMT has a certain effect on relieving RTOM pain and promoting tissue healing. This article reviews the mechanism of PBMT in the treatment of RTOM.

Key words: photobiomodulation therapy, radiation-induced oral mucositis, mechanism

中图分类号:

R781.59

陈敬儒,李凤丹,江银华. 光生物调节疗法治疗放射性口腔黏膜炎作用机制研究进展[J]. 口腔医学, 2023, 43(12): 1134-1139.

CHEN Jingru,LI Fengdan,JIANG Yinhua. Progress of research on the mechanism of photobiomodulation therapy for radiation-induced oral mucositis[J]. Stomatology, 2023, 43(12): 1134-1139.

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