婴幼儿唇腭裂修补全麻术后运用右旋美托咪定预防患儿苏醒期躁动的效果研究

doi:10.13591/j.cnki.kqyx.2022.02.008

Abstract

Abstract: Objective To study the effect of dexmedetomidine on preventing restlessness during awakening after general anesthesia for cleft lip and palate repair in infants. Methods Sixty infants with cleft lip and palate admitted to our hospital from December 2017 to December 2019 were randomly divided into study group (30 cases) and control group (30 cases) according to a random number table method. The children were all given sevoflurane inhalation maintenance after induction of conventional anesthesia. Then the control group was given 1 μg/(kg·h) of normal saline for continuous pumping maintenance, while the study group was given dexmedetomidine of the same volume for pumping maintenance. The hemodynamic indexes, blood gas analysis indexes and agitation indexes of these two groups were compared. Results There was no significant difference in HR and MAP between the two groups at T0, T1 and T2 stages (P>0.05). HR and MAP of the study group at T3, T4 and T5 stages were significantly lower than those of the control group (P<0.05). The pH value of the study group in T5 phase was significantly lower than that of the control group. The pH value in T5 phase of the control group was significantly higher than that in T0 phase (P<0.05), while the pH value in T5 phase of the study group was not significantly different from that in T0 phase (P>0.05). PaCO₂ of the study group at T5 stage was significantly higher than that of the control group (P<0.05), while there was no statistically significant difference in both groups at T5 stage and T0 stage (P>0.05). The agitation score, incidence rate of suture hemorrhage and pain score in the study group were significantly lower than those in the control group (P<0.05). There was no significant difference during the period between two compared groups of children from stopping inhaling sevoflurane to reaching the extubation indication with opening eyes (P>0.05). Conclusion Dexmedetomidine can significantly reduce the risk of restlessness in recovery period after general anesthesia for cleft lip and palate repair in infants and simultaneously stabilize hemodynamics, which is beneficial to anesthesia management.

Key words: dexmedetomidine, repair of cleft lip and palate for infants, hemodynamics, restlessness during awakening

CLC Number:

R782.2

ZHANG Lijuan, LI Chenxi, CHEN Siyu, MAImaitituxun·Tuerdi, LI Weidong. Study on the effect of dexmedetomidine on prevention of restlessness during recovery period of infants after general anesthesia for cleft lip and palate repair[J]. Stomatology, 2022, 42(2): 140-143.

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Study on the effect of dexmedetomidine on prevention of restlessness during recovery period of infants after general anesthesia for cleft lip and palate repair

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