Abstract: Objective To evaluate the efficacy of concentrated growth factor (CGF) in combination with minocycline hydrochloride ointment in relieving pain, controlling inflammation, and promoting the growth of new granulation tissue in tooth sockets. Methods A total of 40 patients with dry socket who were admitted to the Maxillofacial Surgery Department of The Affiliated Stomatological Hospital of Xinjiang Medical University from March to September 2021 were randomly assigned to two groups. Twenty cases of CGF combined with minocycline hydrochloride ointment (group A) and 20 cases of iodoform gauze (group B) were used to study and compare the clinical efficacy of two different treatment methods for dry socket. Patients were followed up on day 0, 1, 4, 7, 14, and 21. Visual analogue scale (VAS) was used to evaluate the degree of pain. Gingival index (GI) was used to evaluate the degree of gingival inflammation. Granulation tissue (GT) was used to evaluate the degree of soft tissue growth in tooth socket. Results Compared with group B, group A was more effective in relieving pain, controlling inflammation and promoting the growth of new granulation tissue in tooth socket, and the results were statistically different (P<0.05). Conclusion CGF combined with minocycline hydrochloride ointment has a good clinical effect on the treatment of dry socket, which is worthy of reference in clinical practice.

Key words: dry socket, concentrated growth factor, minocycline hydrochloride ointment