Stomatology ›› 2023, Vol. 43 ›› Issue (3): 282-288.doi: 10.13591/j.cnki.kqyx.2023.03.018

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Advances in the study on cytokines related to dental pulp regeneration

YAO Minhui1,WU Jintao2,ZHOU Yu3,CHU Fengqing3,JIANG Jiajia3,CHEN Yue3,ZHOU Lili2(),LI Zehan2()   

  1. 1 Department of Oral Medicine, School of Stomatology, Nanjing Medical University, Nanjing 210029,China
  • Revised:2022-06-18 Online:2023-03-28 Published:2023-04-06

Abstract:

With the development of molecular biology, biomaterials and tissue engineering, regenerative treatment of pulpal and periradicular diseases is facing new opportunities. At present, a large number of studies on dental pulp regeneration reveal that cytokines are essential for promoting migration, proliferation and osteogenic differentiation of dental pulp stem cells. In this paper, we review several kinds of cytokines related to dental pulp regeneration, and analyze their roles and regulatory mechanisms in dental pulp regeneration.

Key words: dental pulp regeneration, angiogenesis, cytokines, signal molecule, signaling pathway, SDF-1, CXCL-12, axis, CXCR4, concentrated growth factor

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