Abstract: Objective To compare the effect of triple antibiotic paste and double antibiotic paste on pulp revascularization of young permanent teeth and the level of bFGF/VEGF. Methods One hundred and sisteen patients (116 teeth) with pulpitis who underwent pulp revascularization of young permanent teeth in our hospital were randomly divided into two groups (58 cases in each group). Triple antibiotic paste (triple group) and double antibiotic paste (double group) were used for root canal sealing respectively. The surgical efficacy, the level of cytokines in gingival crevicular fluid and the rate of root canal infection were compared between two groups. Results Compared with before treatment, VAS scores of two groups at 3, 6 and 12 months after operation decreased significantly with the extension of postoperative time (P<0.05), but there was no statistically significant difference between the two groups at 3, 6 and 12 months after operation (P＞0.05). Compared with before operation, levels of bFGF and VEGF in gingival crevicular fluid, root canal wall thickness and root length increased significantly 6 months after operation (P<0.05), but there was no significant difference between the two groups (P＞0.05). The total effective rate of triple group was 96.55%; compared with that of double group (94.83%), the difference was not statistically significant (P＞0.05). There was no significant difference in the incidence of filling material falling off, periapical periodontitis, root canal infection and root fracture between the triple group and the double group (P＞0.05), but the tooth discoloration rate in the triple group was significantly higher than that in the double group (P<0.05). Conclusion Triple antibiotic paste and double antibiotic paste used in pulp revascularization of young permanent teeth can both obtain good revascularization effect. They have same curative effects and good safety, but the tooth discoloration rate of double antibiotic paste is lower and the aesthetics of affected teeth is better.

Key words: pulp revascularization, young permanent teeth, antibiotic paste, pulp necrosis