Stomatology ›› 2022, Vol. 42 ›› Issue (8): 737-740.doi: 10.13591/j.cnki.kqyx.2022.08.012

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Progress of research on the local role of FAM20C in tooth formation

WANG Ning, XIE Xiaohua   

  1. Department of Pediatric Stomatology, The Second Affiliated Hospital of Harbin Medical University,Harbin 150086, China
  • Revised:2022-02-05 Published:2022-08-30

Abstract: Tooth development is a complex process induced by epithelium and mesenchymal mutually and involves many kinds of molecular interactions. It has been found that FAM20C is one of the major molecules involved in tooth development, and it can phosphorylate secretory calcium-binding phosphoprotein (SCPP), promote the differentiation of odontoblasts, ameloblasts, osteoblasts and fibroblasts, as well as the mineralization of enamel and dentin, and maintain the normal shape and health of periodontium. In this paper, the local role of FAM20C in tooth formation is reviewed.

Key words: FAM20C, tooth development, phosphorylation

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