药物性牙龈肥大动物模型的建立及相关机制

doi:10.13591/j.cnki.kqyx.2022.10.014

Abstract

Abstract: Anti-seizure medication, calcium channel blocker and immune suppressor can cause gingival fibrosis and volume increase. In the past two decades, studies have explored the mechanism of drug-induced gingival overgrowth from aspects of epidemiology, clinical experiments and cytology. Subject to patient number and ethics, further investigation of mechanism and treatment relies on the establishment of animal model. This article reviews the research progress of animal model, relevant mechanism and influencing factors, in order to provide a reference for researchers to establish reliable animal models.

Key words: drug-induced gingiva enlargement, animal model, disease model

CLC Number:

R781.4

LI Jiabo, ZANG Wenli, PAN Yaping. Establishment of animal model of drug-induced gingival enlargement and underlying mechanism[J]. Stomatology, 2022, 42(10): 938-941.

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Establishment of animal model of drug-induced gingival enlargement and underlying mechanism

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