颞下颌关节骨关节炎病理性钙化机制及精准防治策略

doi:10.13591/j.cnki.kqyx.2025.08.001

Abstract

Abstract:

Temporomandibular joint osteoarthritis(TMJ-OA) is a chronic disorder characterized by degeneration of articular cartilage, pain, and functional impairment, with pathological calcification serving as a central pathological hallmark closely associated with disease progression. Recent studies have demonstrated that pathological calcification accelerates joint destruction by altering cartilage biomechanical properties, activating inflammatory responses, and promoting matrix degradation pathways. This review systematically reviews the critical role of pathological calcification in the pathogenesis of temporomandibular joint osteoarthritis(TMJ-OA), with a focus on molecular mechanisms including key signaling pathways, autophagy-derived calcifying vesicles, lysosomal destabilization and organelle crosstalk. It further summarizes novel intervention strategies such as pharmacological treatments, gene therapy, and nanotechnology-based approaches, thereby providing a theoretical foundation for the precise prevention and treatment of TMJ-OA.

Key words: pathological calcification, osteoarthritis, chondrocyte, calcified vesicles

CLC Number:

R782.6

HAN Xiaoxiao, QIN Wenpin, JIAO Kai. Pathological calcification in temporomandibular joint osteoarthritis: Mechanisms and targeted therapeutic strategies[J]. Stomatology, 2025, 45(8): 561-566.

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Pathological calcification in temporomandibular joint osteoarthritis: Mechanisms and targeted therapeutic strategies

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