Abstract: Objective To investigate the therapeutic effect of Huashi Xingyu Qingre decoction on oral lichen planus.Methods 30 cases of OLP patients and 30 normal people were selected and the content of ALT,AST,LDH in saliva was detected by automatic biochemical analyzer,the OLP patients were treated by Huashi Xingyu Qingre decoction,and the clinical effect 6 weeks after treatment and the changes of ALT,AST,LDH in saliva before and after treatment were observed.Results In the group of patients with OLP by Huashi Xingyu Qingre decoction 6 weeks after treatment,symptoms disappeared or reduced to different degrees,and hyperemia,erosion,white lesions disappeared or reduced; in the group of patients with OLP,its LDH content in saliva was significantly higher than that of the normal control group.There was no obvious difference between OLP group and the control group in ALT,AST content,but the content of LDH by Huashi Xingyu Qingre decoction reduced obviously in the saliva 6 weeks after treatment.Conclusions Huashi Xingyu Qingre decoction has obvious clinical effect on oral lichen planus; Salivary ALT,AST levels had no significant relationship with OLP,and the increased LDH levels may be associated with the occurrence of OLP.

Key words: Huashi Xingyu Qingre decoction, Oral lichen planus, ALT, AST, LDH