术前TPF诱导化疗在中晚期口腔鳞癌治疗中的初步评估

Abstract

Abstract: Objective To evaluate the clinical effect of preoperation induction chemotherapy with TPF for advanced oral squamous cell carcinoma.Methods From June 2008 to June 2010,48 patients with advanced oral squamous cell carcinoma received induction chemotherapy (D1 Docetaxel 75 mg/m2,D1 Cisplatin 75 mg/m2,D1D5 5fluorouracil 750 mg/m2).Two week after two cycles of chemotherapy,the effects before and after chemotherapy were compared based on the tumor volume and the effects.All cases were divided into complete response (CR),partial response(PR),stable disease(SD) and progressive disease(PD),and CR+PR were effective cases.Results The overall response rate was 58.33%（28/48）with 2 cases of CR，26 cases of PR，18 cases of SD and 2 cases of PD,with no serious adverse reactions.Conclusions Induction chemotherapy with TPF can decrease the tumor volume of advanced oral squamous cell carcinoma significantly.The shortterm effects of this method are marked,while further observation will be needed for the evaluation of longterm effects.

Key words: Oral Squamous Cell Carcinoma, TPF, Induction Chemotherapy

CLC Number:

R739.85

References

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Preliminary evaluation of pre-operation induction chemotherapy with TPF for advanced oral squamous cell carcinoma

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