CD105在口腔鳞癌中表达及与病理特征和预后相关性研究

Abstract

Abstract: Objective To investigate the expression of CD105 in oral squamous cell carcinoma (OSCC) and to probe into CD105′s correlations with the pathological characteristics and prognosis in OSCC.Methods Immunohistochemistry was used to mark vascular endothelial cells in the normal tissue group and OSCC tissue groups by antiCD105 antibody,to measure MVD (Microvessel Density),and to analyze the correlations between CD105MVD and the pathological characteristics and prognosis in OSCC.Results A positive stain of CD105 was observed in OSCC,which significantly differed from the normal tissue group (P＜0.05); In the OSCC tissue group,the expression of CD105 was associated with the degree of differentiation,clinical stage,T classification and lymph node metastasis (P＜0.05),but not with age,sex or smoking（P≥0.05).Besides,the fiveyear survival rates of patients with high CD105MVD were lower than that of patients with low CD105MVD (P＜0.05).Conclusions CD105 has no correlation with age,sex or smoking,but has a relationship with the degree of differentiation,clinical stage,T classification,lymph node metastasis and prognosis in OSCC.Besides,the low survival rates of patients with high CD105MVD can be referred to as an index of prognosis.

Key words: oral squamous cell carcinoma, MVD, CD105

CLC Number:

R739.81

References

[1]Folkman J.Angiogenesis and breast cancer[J].J Clin Oncol,1994,12:441-443
[2]Miyata Y,Sagara Y,Watanabe S,et al.CD105 is a more appropriate marker for evaluating angiogenesis in urothelial cancer of the upper urinary tract than CD31 or CD34[J].Virchows Arch,2013,463(5):673-679
[3]Ke ZF,He S,Li S,et al.Expression characteristics of astrocyte elevated gene1 (AEG1) in tongue carcinoma and its correlation with poor prognosis[J].Cancer Epidemiol,2013,37(2):179-185
[4]Cooper JS,Pajak TF,Forastiere AA,et al.Postoperative concurrent radiotherapy and chemotherapy for highrisk squamouscell carcinoma of the head and neck[J].N Engl J Med,2004,350(19):1937-1944
[5]Wang X,Chen X,Fang J,et al.Overexpression of both VEGFA and VEGFC in gastric cancer correlates with prognosis,and silencing of both is effective to inhibit cancer growth[J].Int J Clin Exp Pathol,2013,6(4):586-597
[6]de Oliveira MV,Pereira Gomes EP,Pereira CS,et al.Prognostic value of microvessel density and p53 expression on the locoregional metastasis and survival of the patients with head and neck squamous cell carcinoma[J].Appl Immunohistochem Mol Morphol,2013,21(5):444-451
[7]王辅林,韦立新,陈乐真.血管内皮生长因子、微血管密度与乳腺癌淋巴结转移及预后的关系[J].中华病理学杂志,2000,29(3):172-175
[8]Manel N,Unutmaz D,Littman DR.The differentiation of human T(H)17 cells requires transforming growth factorbeta and induction of the nuclear receptor RORgammat[J].Nat Immunol,2008,9(6):641-649
[9]Jordanova ES,Gorter A,Ayachi O,et al.Human leukocyte antigen class Ⅰ,MHC class Ⅰ chainrelated molecule A,and CD8+/regulatory Tcell ratio:which variable determines survival of cervical cancer patients?[J].Clin Cancer Res,2008,14(7):2028-2035
[10]Elliott RL1,Blobe GC.Role of transforming growth factor beta in human cancer[J].J Clin Oncol,2005,23(9):2078-2093
[11]李骞,马传香,孙玉英,等.原发性肝癌患者CDl05、VEGF及TGFbeta表达及临床意义[J].山东医药,2011,51(47):105-106
[12]Wang JM,Kumar S,Pye D,et al.Breast carcinoma:comparative study of tumor vasculature using two endothelial cell markers[J].J Natl Cancer Inst,1994,86(5):386-388
[13]Pericacho M,Velasco S,Prieto M,et al.Endoglin haploin sufficiency promotes fibroblast accumulation during wound healing through Akt activation[J].Plos One,2013,8(1):e54687-
[14]Zvrko E,Mikic A,Vuckovic L.Clinicopathologic significance of CD105assessed microvessel density in glottic laryngeal squamous cell carcinoma[J].Auris Nasus Larynx,2010,37(1):77-83
[15]张继贤,赵莺.CD105在恶性胸膜间皮瘤微血管中的表达及意义[J].现代实用医学,2013,25(4):407-409
[16]Eshghyar N,Mohammadi N,Rahrotaban S,et al.Endoglin (CD105) positive microvessel density and its relationship with lymph node metastasis in squamous cell carcinoma of the tongue[J].Arch Iran Med,2011,14(4):276-280
[17]季芳.肿瘤微环境影响卵巢癌生物学行为的研究进展[J].国际妇产科学杂志,2012,39(4):352-355
[18]李丙华，徐娅苹.CD105标记的微血管密度与喉癌临床病理特征相关性[J].中国耳鼻喉头颈外科,2004,11(6):342-345
[19]Marioni G,Staffieri A,Manzato E,et al.A Higher CD105Assessed Microvessel Density and Worse Prognosis in Elderly Patients with Laryngeal Carcinoma[J].Arch Otolaryngol Head Neck Surg,2011,37(2):175-180
[20]Lee NY,Golzio C,Gatza CE,et al.Endoglin regulates PI3kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis[J].Mol Biol Cell,2012,23(13):2412-2423

Expression of CD105 and its correlations with pathologic characteristics and prognosis in oral squamous cell carcinoma

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	. Construction of clinical prognostic model of oral squamous cell carcinoma based on immune-related genes [J]. , 2022, 42(10): 869-877.
[2]	. Mechanism research of YAP1-FOS promoting cell proliferation, migration and EMT in oral squamous cell carcinoma [J]. , 2019, 39(7): 581-586.
[3]	. Advances in the study of factors related to the occurrence and development of oral squamous cell carcinoma mediated by PI3K/AKT pathway [J]. , 2019, 39(6): 552-556.
[4]	. Inhibitory effect of danshensu on oral squamous cell carcinoma CAL-27 cells in vitro [J]. , 2019, 39(2): 113-116.
[5]	. A clinicopathological study of the prognosis and metastasis of MMP-14 in oral cancer patients [J]. , 2018, 38(8): 685-689.
[6]	. DNA quantitative analysis of oral squamous cell carcinoma and its clinical significance [J]. , 2018, 38(7): 616-619.
[7]	. Influence of nobelitin on the proliferation，migration and invasion of oral squamous cell carcinoma Cal-27 cells [J]. , 2018, 38(6): 481-484.
[8]	. Non-invasive Human Papilloma Virus Detection of Oral leukoplakia and Squamous Cell Carcinomas [J]. , 2018, 38(6): 528-532.
[9]	. Expression regulation of microRNA and oral squamous cell carcinoma [J]. , 2018, 38(5): 476-480.
[10]	. Relationship between E-cadherin and MMP-1 expressions and prognosis in oral squamous cell carcinoma [J]. , 2018, 38(1): 39-43.
[11]	. Effect of staurosporine on cell proliferation and apoptosis in oral squamous cell carcinoma cell line CAL27 [J]. , 2017, 37(7): 598-602.
[12]	chen xin. Current situation of oral squamous cell carcinoma [J]. , 2017, 37(5): 462-465.
[13]	. The expressions of Slug and E-cadherin in oral squamous cell carcinoma [J]. , 2017, 37(3): 214-218.
[14]	. The prognostic significance of peripheral blood eosinophilia in oral squamous cell carcinoma after surgery [J]. , 2016, 36(6): 546-549.
[15]	. MicroRNA27b inhibits cell proliferation of oral squamous cell carcinoma through targeting FZD7 [J]. , 2016, 36(3): 200-205.