Abstract: Objective Interleukin-17 (IL-17) polymorphisms have been testified by a few studies to be associated with several immune inflammatory disease. The aim of present study was to explore whether the single nucleotide polymorphisms (SNPs) in IL-17A (rs2275913) and IL-17F (rs763780) genes were correlated with the susceptibility to aggressive periodontitis (AgP) in Chinese Han population. Methods 87 AgP patients and 79 healthy controls were recruited in this study. Genomic DNA was extracted from the peripheral blood samples, and gene polymorphisms were determined by multiplex SNaPshot technique. Results No significant differences were observed in genotype or allele frequency distributions of IL-17A (rs2275913) and IL-17F (rs763780) between AgP and healthy controls (P≥0.05). However, the A allele frequencies of IL-17A (rs2275913) were significantly higher in AgP patients compared with healthy controls (54.0% vs.42.4%, P=0.034, OR=1.596, 95%CI=1.034-2.463). Conclusion These findings indicate that the IL-17A (rs2275913) polymorphism seemed to be a genetic risk factor of AgP. It suggests that the IL-17A(rs2275913) polymorphism may be associated with the susceptibility to AgP in Chinese Han population.

Key words: Interleukin-17, Polymorphisms, Aggressive periodontitis