miR-34a在口腔医学领域中的研究进展

Abstract

Abstract: Abstracts: MicroRNAs (miRNAs) are endogenously expressed small noncoding RNAs that regulate gene expression by either inhibiting translation or by inducing degradation of their target messenger RNAs (mRNAs). Among lots of miRNAs, miR-34a is a kind of miRNAs that is recently discovered and attracts much attention. Current researches on miR-34a mainly focus on its antitumor effect while its role in oral diseases lacks attention. This review argues that miR-34a can inhibit periodontitis inflammatory responses and the invasion of tongue squamous cell carcinoma (TSCC), and it can also promote cytodifferentiation of human dental papilla cells. Besides, current reports of miR-34a in the field of oral medicine are reviewed to lay a foundation for further understanding the roles of miR-34a in oral diseases.

Key words: miR-34a, periodontitis, osteoclast differentiation, tongue squamous cell carcinoma, dental papilla cell differentiation

CLC Number:

R780.2

References

[1] Lee RC, Feinbaum RL, AmbrosV.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J] . Cell,1993, 75( 5) : 843-854.
[2] Li XJ, Ren ZJ，Tang JH. MicroRNA-34a: a potential therapeutic target in human cancer[J]. Cell Death Dis,2014, 5:e1327.
[3] Krzeszinski JY , Wei W , Huynh H, et al. miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.[J] Nature,2014,512(7515):431-5.
[4] Lee YH, Na HS, Jeong SY, et al. Comparison of inflammatory microRNA expression in healthy and periodontitis tissues[J]. BIOCELL,2011, 35(2): 43-49.
[5] Jiang P, Liu R, Zheng Y, et al. MiR-34a inhibits lipopolysaccharide-induced inflammatory response through targeting Notch1 in murine macrophages[J]. Exp Cell Res,2012,318(10):1175-84.
[6] Agarwal S, Baran C, Piesco NP，et al. Synthesis of proinflammatory cytokines by human gingival fibroblasts in response to lipopolysaccharides and interleukin-1 beta[J].J Periodontal Res, 1995,30(6):382-9.
[7] Hawiger J.Innate immunity and inflammation: a transcriptional paradigm[J].Immunol Res,2001,23(2-3):99-109.
[8] Hayden MS, Ghosh S.Signaling to NF-kappaB[J].Genes Dev, 2004 , 18(18):2195-224.
[9] Monsalve E, Ruiz-Garcia A, Baladron V, et al. Notch1 upregulates LPS-induced macrophage activation by increasing NF-kappaB activity[J] .Eur J Immunol, 2009, 39(9):2556-70.
[10] Palaga T, Buranaruk C, Rengpipat S, et al.Notch signaling is activated by TLR stimulation and regulates macrophage functions[J].Eur J Immunol,2008, 38(1):174-83.
[11] Kitaura H, Kimura K, Ishida M,et al. Immunological Reaction in TNF-α-Mediated Osteoclast Formation and Bone Resorption In Vitro and In Vivo[J]. Clin Dev Immunol. 2013,2013: 181849.
[12] Ejeil AL, Gaultier F, Igondjo-Tchen S, et al. Are cytokines linked to collagen breakdown during periodontal disease progression [J] ? J Periodontol. 2003; 74:196–201.
[13] Graves DT. The potential role of chemokines and inflammatory cytokines in periodontal disease progression[J]. Clin Infect Dis. 1999; 28:482–490.
[14] Sasakia H, Suzukib N, AlShwaimic E,et al.18beta-Glycyrrhetinic Acid Inhibits Periodontitis Via Glucocorticoid-Independent NF–κB Inactivation In IL-10 Deficient Mice[J]. J Periodontal Res. 2010,45(6): 757–763.
[15] Jia LF, Wei SB, Mitchelson K，et al.miR-34a Inhibits Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting MMP9 and MMP14[J]. PloS One, 2014 ,9(9):e108435.
[16] Wan M, Gao B, Sun F，et al. microRNA miR-34a Regulates Cytodifferentiation and Targets Multi-signaling Pathways in Human Dental Papilla Cells[J]. PloS One, 2012,7(11):e50090.
[17] Jarvinen E, Salazar-Ciudad I, Birchmeier W, et al. Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling[J]. Proc Natl Acad Sci U S A, 2006, 103(49): 18627–18632.
[18] Munne PM, Tummers M, Jarvinen E, et al. Tinkeringwith the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction[J]. Development,2009, 136(3): 393–402.
[19] Munne PM, Felszeghy S, Jussila M, et al. Splitting placodes: effects of bone morphogenetic protein and Activin on the patterning and identity of mouse incisors[J]. Evol Dev ,2010,12(4): 383–392.
[20] Michon F .Tooth evolution and dental defects: from genetic regulation network to micro-RNA fine-tuning[J]. Birth Defects Res A Clin Mol Teratol ,2011,91(8):763–769.

Research progress of miR-34a in the field of stomatology

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	zi zhenYang. Application of glycine air polishing in plaque control [J]. , 2022, 42(7): 641-644.
[2]	. Serum visfatin and liptin levels and their associations with periodontal indices in patients with periodontitis in plateau section [J]. , 2022, 42(1): 65-68.
[3]	. Diagnosis and treatment of radicular cyst resulting from apical periodontitis of primary teeth: A case report [J]. , 2021, 41(11): 1016-1018.
[4]	. Analysis of periodontal health status and influencing factors of middle-aged and elderly people in Jiangsu Province [J]. , 2020, 40(3): 244-248.
[5]	. Research progress on the relationship between alcohol consumption and periodontitis [J]. , 2020, 40(12): 1138-1142.
[6]	. Application of CBCT in the evaluation of resolution of maxillary sinus mucositis from maxillary teeth with apical periodontitis after endodontic treatment [J]. , 2019, 39(7): 612-615.
[7]	. Mesoporous silica coated Au Nanobipyramids nanoparticle for near-infrared responsive drug delivery system and its application in antibacteria [J]. , 2019, 39(5): 404-408.
[8]	. Research progress of matrix metalloproteinases as modulators of periodontitis [J]. , 2019, 39(3): 271-274.
[9]	Xu -Zheng shan lingGan. Research progress on the metabolism of patients with type 2 diabetes mellitus via periodontal non-surgical treatment. [J]. , 2019, 39(2): 183-187.
[10]	. The role of TNF-α/ NF κB signaling pathway and its antagonism in periodontitis pathogenesis and periodontal tissue regeneration [J]. , 2019, 39(1): 1-5.
[11]	. Analysis of inhibitory effects of three endodontic irrigations on the pathogens in root canals [J]. , 2019, 39(1): 25-29.
[12]	. Research progress on the role of Th17 cells in periodontitis [J]. , 2019, 39(1): 77-80.
[13]	. Research on the present situation of interplay of type 2 diabetes mellitus, chronic periodontitis and non-surgical periodontal treatment [J]. , 2018, 38(9): 839-843.
[14]	. The relationship between Treponema denticola and periodontal pocket sulfide levels in chronic periodontitis [J]. , 2018, 38(9): 791-794.
[15]	. Efficacy evaluation of root canal disinfectant alleviating clinical symptoms of periapical periodontitis of primary molar teeth [J]. , 2018, 38(8): 728-730.