›› 2015, Vol. 35 ›› Issue (6): 504-507.

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Research progress of the role of IGF -Ⅰ in temporomandibular joint cartilage under stress

  

  • Received:2015-02-05 Revised:2015-04-01 Online:2015-06-28 Published:2015-07-01

Abstract: The condylar cartilage in TMJ (temporomandibular joint) stress sensitive area is closely related to the growth and remodeling of the mandible. Under stress, condylar cartilage can respond to mechanical stimuli, thereby contributing to the proliferation and differentiation of condylar cartilage cells. IGF (insulin-like growth factor) -Ⅰ plays an important part in the growth and development of the condylar cartilage, and has a biological effect by binding itself to receptors. Meanwhile, IGF-Ⅰ under stress stimuli will lead to the synthesis of condylar cartilages and is involved in condylar remodeling. This article focused on IGF-Ⅰ and its relevant performance in the temporomandibular joint under stress, so as to further clarify the mechanism of IGF-Ⅰ in temporomandibular joint cartilage under stress.

Key words: stress, IGF-Ⅰ, temporomandibular joint cartilage, alterations

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