硫酸软骨素应用于骨修复材料中的研究进展

doi:10.13591/j.cnki.kqyx.2023.01.015

Abstract

Abstract:

Chondroitin sulfate is an important component of extracellular matrix (ECM) in animal and human body. In recent years, chondroitin sulfate has been proven to have potential efficacy in biomedical application and has been widely used in bone regeneration and osteogenesis, especially in craniofacial reconstruction and dental medicine. Research shows that chondroitin sulfate derivatives and chondroitin sulfate composite scaffolds have great potential in promoting osteogenesis and biomineralization. However, due to the variety of chondroitin sulfate and various application forms, study on its mechanism of osteogenic repair is still insufficient. In this paper, biological characteristics, bone regeneration and osteogenesis of chondroitin sulfate, its application in different biomaterial design and future prospect are discussed.

Key words: chondroitin sulfate, bone regeneration, osteogenesis, bone tissue engineering

CLC Number:

R783.1

ZHANG Qian, WANG Chang, LIANG Chen, QU Xingyuan, LIU Yue, YAN Baojun, WANG Lei. Progress of research on application of chondroitin sulfate in osteogenic repair materials[J]. Stomatology, 2023, 43(1): 88-91.

References 32

[1]	韩倩倩, 赵君, 王苗苗, 等. 组织工程产品用种子细胞的质量控制与标准化[J]. 组织工程与重建外科杂志, 2020, 16(4):324-327.
[2]	Li YM, Wu JY, Jiang J, et al. Chondroitin sulfate-polydopamine modified polyethylene terephthalate with extracellular matrix-mimetic immunoregulatory functions for osseointegration[J]. J Mater Chem B, 2019, 7(48):7756-7770. doi: 10.1039/C9TB01984G
[3]	Gavva C, Patel K, Kudre T, et al. Glycosaminoglycans from fresh water fish processing discard-Isolation, structural characterization, and osteogenic activity[J]. Int J Biol Macromol, 2020, 145:558-567. doi: 10.1016/j.ijbiomac.2019.12.189
[4]	Ida-Yonemochi H, Morita W, Sugiura N, et al. Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1[J]. Sci Rep, 2018, 8(1):17134. doi: 10.1038/s41598-018-35412-5 pmid: 30459452
[5]	Yang J, Shen MY, Wen HL, et al. Recent advance in delivery system and tissue engineering applications of chondroitin sulfate[J]. Carbohydr Polym, 2020, 230:115650. doi: 10.1016/j.carbpol.2019.115650
[6]	Niu QF, Li GY, Li C, et al. Two different fucosylated chondroitin sulfates:Structural elucidation, stimulating hematopoiesis and immune-enhancing effects[J]. Carbohydr Polym, 2020, 230:115698. doi: 10.1016/j.carbpol.2019.115698
[7]	Ustyuzhanina NE, Bilan MI, Panina EG, et al. Structure and anti-inflammatory activity of a new unusual fucosylated chondroitin sulfate from Cucumaria djakonovi[J]. Mar Drugs, 2018, 16(10):389. doi: 10.3390/md16100389
[8]	Zhu WM, Ji Y, Wang Y, et al. Structural characterization and in vitro antioxidant activities of chondroitin sulfate purified from Andrias davidianus cartilage[J]. Carbohydr Polym, 2018, 196:398-404. doi: 10.1016/j.carbpol.2018.05.047
[9]	Singh BN, Veeresh V, Mallick SP, et al. Design and evaluation of chitosan/chondroitin sulfate/nano-bioglass based composite scaffold for bone tissue engineering[J]. Int J Biol Macromol, 2019, 133:817-830. doi: S0141-8130(18)37309-4 pmid: 31002908
[10]	Simental-Mendía M, Sánchez-García A, Vilchez-Cavazos F, et al. Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis:A systematic review and meta-analysis of randomized placebo-controlled trials[J]. Rheumatol Int, 2018, 38(8):1413-1428. doi: 10.1007/s00296-018-4077-2 pmid: 29947998
[11]	Volpi N. Chondroitin sulfate safety and quality[J]. Molecules, 2019, 24(8):1447. doi: 10.3390/molecules24081447
[12]	Anjum F, Lienemann PS, Metzger S, et al. Enzyme responsive GAG-based natural-synthetic hybrid hydrogel for tunable growth factor delivery and stem cell differentiation[J]. Biomaterials, 2016, 87:104-117. doi: S0142-9612(16)00070-3 pmid: 26914701
[13]	Andrews S, Cheng A, Stevens H, et al. Chondroitin sulfate glycosaminoglycan scaffolds for cell and recombinant protein-based bone regeneration[J]. Stem Cells Transl Med, 2019, 8(6):575-585. doi: 10.1002/sctm.18-0141
[14]	Korotkyi O, Huet A, Dvorshchenko K, et al. Probiotic composi-tion and chondroitin sulfate regulate TLR-2/4-mediated NF-κB inflammatory pathway and cartilage metabolism in experimental osteoarthritis[J]. Probiotics Antimicrob Proteins, 2021, 13(4):1018-1032. doi: 10.1007/s12602-020-09735-7
[15]	Tak PP, Firestein GS. NF-kappaB: A key role in inflammatory diseases[J]. J Clin Invest, 2001, 107(1):7-11. doi: 10.1172/JCI11830 pmid: 11134171
[16]	任光辉. 硫酸软骨素A促进成骨的动物实验研究[D]. 济南: 山东大学, 2012.
[17]	Li YM, Guo XM, Dong SK, et al. A triple-coated ligament graft to facilitate ligament-bone healing by inhibiting fibrogenesis and promoting osteogenesis[J]. Acta Biomater, 2020, 115:160-175. doi: S1742-7061(20)30451-7 pmid: 32791348
[18]	Kim HD, Lee EA, An YH, et al. Chondroitin sulfate-based biomineralizing surface hydrogels for bone tissue engineering[J]. ACS Appl Mater Interfaces, 2017, 9(26):21639-21650. doi: 10.1021/acsami.7b04114
[19]	Ye J, Gong P. NGF-CS/HA-coating composite titanium facilitates the differentiation of bone marrow mesenchymal stem cells into osteoblast and neural cells[J]. Biochem Biophys Res Commun, 2020, 531(3):290-296. doi: 10.1016/j.bbrc.2020.06.158
[20]	Cai MX, Li JH, Yue R, et al. Glycosylation of DMP1 maintains cranial sutures in mice[J]. J Oral Rehabil, 2020, 47(Suppl 1):19-28.
[21]	Kong JC, Wei B, Groth T, et al. Biomineralization improves mechanical and osteogenic properties of multilayer-modified PLGA porous scaffolds[J]. J Biomed Mater Res A, 2018, 106(10):2714-2725. doi: 10.1002/jbm.a.36487 pmid: 30133124
[22]	Elango J, Saravanakumar K, Rahman SU, et al. Chitosan-collagen 3D matrix mimics trabecular bone and regulates RANKL-mediated paracrine cues of differentiated osteoblast and mesenchymal stem cells for bone marrow macrophage-derived osteoclastogenesis[J]. Biomolecules, 2019, 9(5):173. doi: 10.3390/biom9050173
[23]	Croes M, Öner FC, van Neerven D, et al. Proinflammatory T cells and IL-17 stimulate osteoblast differentiation[J]. Bone, 2016, 84:262-270. doi: S8756-3282(16)00011-9 pmid: 26780388
[24]	de Vries TJ, ElBakkali I, Kamradt T, et al. What are the peripheral blood determinants for increased osteoclast formation in the various inflammatory diseases associated with bone loss?[J]. Front Immunol, 2019, 10:505. doi: 10.3389/fimmu.2019.00505 pmid: 30941138
[25]	Largo R, Roman-Blas JA, Moreno-Rubio J, et al. Chondroitin sulfate improves synovitis in rabbits with chronic antigen-induced arthritis[J]. Osteoarthritis Cartilage, 2010, 18(Suppl 1):S17-S23.
[26]	Bonito V, Smits AIPM, Goor OJGM, et al. Modulation of macrophage phenotype and protein secretion via heparin-IL-4 functionalized supramolecular elastomers[J]. Acta Biomater, 2018, 71:247-260. doi: S1742-7061(18)30115-6 pmid: 29518556
[27]	Shen QS, Zhang CH, Mo HZ, et al. Fabrication of chondroitin sulfate calcium complex and its chondrocyte proliferation in vitro[J]. Carbohydr Polym, 2021, 254:117282. doi: 10.1016/j.carbpol.2020.117282
[28]	Shi HS, Ye XL, Zhang J, et al. Enhanced osteogenesis of injectable calcium phosphate bone cement mediated by loading chondroitin sulfate[J]. ACS Biomater Sci Eng, 2019, 5(1):262-271. doi: 10.1021/acsbiomaterials.8b00871
[29]	李筱媛, 葛少华. 支架材料的免疫反应对骨组织再生的影响[J]. 口腔医学, 2018, 38(9):834-838.
[30]	Costantini M, Idaszek J, Szöke K, et al. 3D bioprinting of BM-MSCs-loaded ECM biomimetic hydrogels for in vitro neocartilage formation[J]. Biofabrication, 2016, 8(3):035002. doi: 10.1088/1758-5090/8/3/035002
[31]	Cheng K, Zhu YL, Wang DQ, et al. Biomimetic synthesis of chondroitin sulfate-analogue hydrogels for regulating osteogenic and chondrogenic differentiation of bone marrow mesenchymal stem cells[J]. Mater Sci Eng C Mater Biol Appl, 2020, 117:111368. doi: 10.1016/j.msec.2020.111368
[32]	Reginster JY, Veronese N. Highly purified chondroitin sulfate:A literature review on clinical efficacy and pharmacoeconomic aspects in osteoarthritis treatment[J]. Aging Clin Exp Res, 2021, 33(1):37-47. doi: 10.1007/s40520-020-01643-8

Progress of research on application of chondroitin sulfate in osteogenic repair materials

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 32

Related Articles 15

Recommended Articles 0

Metrics

Comments

[1]	NIU Lina,SHEN Minjuan,FANG Ming. Progress of research on bone grafts for implant dentistry [J]. Stomatology, 2023, 43(1): 11-17.
[2]	. The cause and treatment of congential condyle deformity [J]. , 2022, 42(8): 745-749.
[3]	. Study on drug-loaded magnetic polycaprolactone/gelatin microsphere scaffolds and their osteogenesis behavior in vitro [J]. , 2022, 42(4): 289-0.
[4]	. Effects of age on the biological behavior of human dental pulp stem cells [J]. , 2022, 42(2): 103-109.
[5]	. Experimental study on repairing rabbit mandibular defect with Mg-2Zn-0.5Ca alloy/mineralized collagen [J]. , 2022, 42(12): 1068-1073.
[6]	. Study on the repair effect of simvastatin PCL-GT /PCL barrier membrane on rabbit skull defect [J]. , 2021, 41(12): 1062-1067.
[7]	. Mesenchymal stem cell derived extracellular matrix and its research progress [J]. , 2020, 40(3): 271-274.
[8]	. Effect of autogenous bone graft on distal bone defect of the second molar after the extraction of the impacted third molar [J]. , 2019, 39(7): 624-627.
[9]	. Application of platelet concentrate in oral implantation [J]. , 2019, 39(7): 636-641.
[10]	. Performance study of two new collagen membranes for guiding bone tissue regeneration in vivo and in vitro [J]. , 2019, 39(6): 481-487.
[11]	Yang LIU. The chitosan drug delivery system and its application in bone tissue engineering [J]. , 2019, 39(4): 354-359.
[12]	. Research progress of bone regeneration on jaw defect guided by GBR technique [J]. , 2019, 39(3): 261-265.
[13]	. Application of poly(lactic-co-glycolic acid) in bone tissue engineering scaffold materials [J]. , 2019, 39(2): 167-170.
[14]	. High concentration of zoledronate inhibits osteogenesis differentiation and promotes apoptosis of human periodontal ligament stem cell [J]. , 2019, 39(10): 880-888.
[15]	. Advantages of long-term stability of guided bone regeneration augmentation for alveolar bone reconstruction compared with autogenous bone graft [J]. , 2019, 39(1): 60-62.