口腔-肠道微生物组与辅助生殖的研究进展

doi:10.13591/j.cnki.kqyx.2025.01.001

Abstract

Abstract:

Oral and intestinal microbiota are two of the most complex microbiota in the human body which play important roles in maintaining various physiological balances. Assisted reproductive technology(ART)is an in vitro treatment of gametes and embryos to help women conceive and produce healthy fetuses. Current assisted reproductive technology ART includes in vitro fertilization with or without oocyte intracytoplasmic sperm injection(IVF/ICSI). The ectopic colonization of oral-gut microbiota, their metabolites, and immune regulation mechanisms may affect the outcomes of assisted reproduction. This article mainly reviews the ways, mechanisms and potential beneficial interventions of oral and intestinal microbiota on women receiving artificial assisted reproductive therapy.

Key words: assisted reproductive technology, oral-gut microbes, in vitro fertilization, translocation colonization

CLC Number:

YANG Peiyue, PENG Xian, ZHOU Xuedong. Maternal oral-gut microbiome and artificial assisted reproduction[J]. Stomatology, 2025, 45(1): 1-7.

Figures/Tables 3

References 70

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细菌种类早产孕妇羊水	检测部位PCR^[7,30⇓-32]	检测方法F.n
F.n	早产合并早发性新生儿败血症孕妇脐带血及羊水	PCR、16S RNA测序分析^[33]
F.n	先兆早产孕妇胎盘组织	PCR^[34]
F.n	尾静脉注射牙菌斑后小鼠胎盘血管及羊水	PCR、16S RNA测序分析^[6,35-36]
P.g	先兆早产孕妇羊水	PCR^[37]
P.g	早产孕妇的胎盘组织及羊膜上皮	免疫组织化学染色^[38]
P.g	子痫前期孕妇胎盘组织	下一代测序分析^[39]
Bergeyella.sp	早产合并早发性新生儿败血症孕妇脐带血及羊水	16S RNA测序分析^[33]
Bergeyella.sp	早产病例的羊水	16S RNA测序分析^[40]

Maternal oral-gut microbiome and artificial assisted reproduction

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