应用iRoot BP Plus、MTA直接盖髓后牙髓修复反应变化的大鼠实验研究

doi:10.13591/j.cnki.kqyx.2025.03.006

Abstract

Abstract:

Objective To explore the differences and similarities in the changes of pulp repair response after direct pulp capping with iRoot BP Plus and MTA. Methods A total of 36 male SD rats were randomly divided into 3 groups, namely iRoot BP Plus group, MTA group and blank control group. Dental pulp exposure and direct pulp capping was performed on both sides of maxillary first molars of each rat. Four rats were randomly selected and sacrificed from each group at 7, 14, and 28 days postoperatively, and the specimens were taken for hematoxylin-eosin (HE) staining, and then each index was observed. Results ①From the perspective of dentin tubular formation quality, at 14 d and 28 d, there were statistical differences between iRoot BP Plus group and MTA group(P<0.05), and iRoot BP Plus was significantly better than MTA in terms of quality of restorative dentin formation. ②At 14 days after operation, iRoot BP Plus had a greater area of neodontinin than that in MTA group(P<0.05). Conclusion Both iRoot BP Plus and MTA can promote the formation of restorative dentin bridges after direct pulp capping, and the formation quality is high. The long-term effects need to be further studied.

Key words: iRoot BP Plus, MTA, direct pulp capping, reparative dentinal

CLC Number:

R783.1

HUANG Caixia, ZHANG Ran, LI Jiaojiao, WEI Jiabin, LI Shufang. Study on the changes in dental pulp repair response in rats after direct pulp capping using iRoot BP Plus and MTA[J]. Stomatology, 2025, 45(3): 191-196.

Figures/Tables 7

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References 20

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分级	定义
修复性硬组织
1	修复性硬组织或牙本质桥覆盖全部穿髓孔
2	穿髓孔处见大量修复性硬组织沉积
3	穿髓孔处见少量修复性硬组织沉积
4	穿髓孔处未见修复性硬组织或牙本质桥生成
牙本质小管
0	修复性硬组织中无牙本质小管存在
1	修复性硬组织中可见牙本质小管,但小管排列不规则
2	修复性硬组织中可见牙本质小管,且小管排列规则

时间	组别	n	硬组织桥组织学评分				平均秩	P	牙本质小管组织学评分			平均秩	P
时间	组别	n	1	2	3	4	平均秩	P	0	1	2	平均秩	P
7 d	iRoot BP Plus	8	0	0	7	1	8.50	0.045^*	6	2	0	14.00	0.334
	MTA	8	0	0	5	3	14.50	0.004^#	7	1	0	12.50
	空白组	8	0	0	1	7	14.50	0.046^&	8	0	0	11.00
14 d	iRoot BP Plus	8	3	4	1	0	6.69	0.003^*	1	6	1	17.25	0.003^*
	MTA	8	1	2	4	1	11.81	0.002^#	5	3	0	11.13	0.036^@
	空白组	7	0	1	0	6	18.29	0.019^&	7	0	0	7.00	0.001^#
28 d	iRoot BP Plus	8	6	2	0	0	7.38	0.001^*	0	2	6	18.13	<0.001^*
	MTA	7	4	2	0	1	9.71	<0.001^#	1	5	1	12.43	0.020^@ <0.001^#
	空白组	8	0	1	1	6	18.63	0.006^&	7	1	0	5.50	0.006^&

分组	7 d	14 d	28 d	F	P
iRoot BP Plus(n=24)	6.40±3.22	13.54±1.75	21.74±2.30	75.671	<0.001^*
MTA(n=23)	4.63±4.00	10.79±1.63	17.41±8.51	10.128	0.004^*
空白(n=23)	0.53±1.49	106.00±2.81	3.36±6.23	0.787	0.480
F	12.398	72.274	19.711	—	—
P	0.001^*	<0.001^*	<0.001^*	—	—

Study on the changes in dental pulp repair response in rats after direct pulp capping using iRoot BP Plus and MTA

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