Abstract:

Objective To explore the clinical manifestations, histopathological features and treatment of oral granular cell tumor, in order to provide reference for its diagnosis and treatment. Methods The histopathological features of granular cell tumor diagnosed in our hospital were classified into benign, atypical and malignant according to the six criteria proposed by Fanburg-Smith, and the clinical manifestations, histopathological features and treatment methods of all cases were retrospectively analyzed. Results There were 14 cases in this group, with a predilection age of 40-60 years old (8 cases, 57.14%); the ratio of male to female was 1∶1, 12 cases (85.71%) in the tongue, 1 case in the cheek and 1 case in the sublingual gland. The main manifestations were painless slow growing nodules or masses. Nine cases (64.29%) had no obvious clinical symptoms; 4 cases (28.57%) had pain and numbness of the tongue, and 1 case had fixation of the tongue, resulting in difficulty in swallowing and speech. Pathological findings showed that the tumors were composed of abundant eosinophils with a large number of homogeneous granules in the cytoplasm. There were 8 cases of benign (57.14%), 2 cases of atypical (14.29%), and 4 cases of malignant (28.57%). All cases received surgical treatment. One malignant patient was lost to follow-up after 2 years, and the prognosis of other cases was good. Conclusion Oral granular cell tumors are mainly benign tumors of the tongue, and their treatment key points vary according to its histopathological types. Surgical resection is the main treatment plan, and the overall prognosis is good.

Key words: granular cell tumor, clinicopathological feature, treatment method