Objective To provide reference for clinical selection of fluid resins by comparing the bonding properties of Beautifil Flow Plus F00, FiltekTM Z350 XT, SDR, Tetric® N-Flows and Constic with tooth enamel. Methods Fifty adult extrinsic premolars were selected for orthodontic extraction and randomly divided into five groups(n=10), namely F00 group, Z350 group, SDR group, Tetric group and Constic group, and each group was a parallel control group. One third of the cheek of each isolated tooth was removed by grinding the enamel with the thickness of 0.5 mm, and a circular shape with a diameter of 3 mm was used as the bonding surface. Ten cylindrical resin specimens with a diameter and length of 3 mm were prepared for bonding with the prepared tooth enamel surface, and self-coagulation resin was embedded. After 3 000 times of alternating cold and hot cycles and 24 h of constant temperature water bath at 37 ℃, the shear strength test was carried out; the data were recorded, and the cut bonding interface was observed under scanning electron microscope. Results The shear strength of group F00 was (18.39±2.93)MPa, and that of group Z350 was(11.03±1.55)MPa. The shear strength of, SDR group was (12.77±1.55)MPa;Tetric group was (15.25±1.88)MPa and Constic group was(12.79±2.78)MPa. ANOVA test and SNK test were performed on the obtained data. The shear strength of F00 group was significantly higher than that of Z350 group, SDR group, Tetric group and Constic group(P<0.05). The shear strength of Tetric group was significantly higher than that of Z350 group, SDR group and Constic group(P<0.05). There was no significant difference in shear strength among Z350 group, SDR group and Constic group(P>0.05). Conclusion Among the five fluid resins, Beautifil Flow Plus F00 fluid resin has the highest bonding performance, followed by Tetric® N-Flow fluid resin, and FiltekTM Z350 XT, SDR and Constic fluid resin have low bonding performance.