Copine7蛋白在牙、牙周组织发育与再生中的作用

doi:10.13591/j.cnki.kqyx.2023.07.012

摘要/Abstract

摘要：

Copine 7(CPNE7)蛋白是在前成釉细胞条件培养基(preameloblast-conditioned medium,PACM)中发现的一种钙离子依赖性磷脂结合蛋白。在牙发育过程中,CPNE7蛋白由牙源性上皮细胞表达并分泌,参与调控牙源性间充质细胞向成牙本质细胞分化。近年研究发现,CPNE7蛋白可促进第三期牙本质的形成和牙本质小管内矿物沉积,降低牙本质通透性,在牙本质损伤修复方面有重要的临床应用前景。此外,CPNE7蛋白可促进牙骨质的形成,但与牙周膜的形成无明显关系。本文对CPNE7蛋白在牙本质和牙周组织发育中的作用及其机制作一综述,以期为相关疾病的治疗提供新的思路和方向。

关键词: Copine7, 牙本质, 牙周组织, 组织再生, CPNE7衍生物

Abstract:

Copine 7(CPNE7), a calcium phospholipid-binding protein found in preameloblast-conditioned medium(PACM), is initially expressed and secreted by dental epithelial cells. CPNE7 plays an important role in the differentiation of dental mesenchymal cells to odontoblasts. Recently, accumulating evidence has demonstrated that CPNE7 can induce the tertiary dentin formation and reduce the permeability of dentin by promoting mineral deposition in dentinal tubules, which allows CPNE7 to be applied in dentin repair. Besides, CPNE7 has shown positive effects on cementogenesis, but has no obvious relationship to the formation of periodontal ligament(PDL). In this study, we summarized research progress of the roles and mechanisms of CPNE7 in the development of dentin and periodontium, offering new approaches to treating related diseases.

Key words: Copine 7, dentin, periodontium, tissue regeneration, CPNE7 derivative

中图分类号:

R781.4

杨玥, 赵溟昱, 谢旭东, 王骏. Copine7蛋白在牙、牙周组织发育与再生中的作用[J]. 口腔医学, 2023, 43(7): 647-651.

YANG Yue, ZHAO Mingyu, XIE Xudong, WANG Jun. Roles of Copine 7 in the development and regeneration of teeth and periodontium[J]. Stomatology, 2023, 43(7): 647-651.

图/表 2

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