一氧化氮在牙周炎进展中的作用机制与应用

doi:10.13591/j.cnki.kqyx.2023.10.014

摘要/Abstract

摘要：

一氧化氮是一种半衰期较短的小分子自由基,可穿透细胞膜进行细胞间信号传递。研究发现,一氧化氮在牙周组织中发挥双重作用:生理条件下可促进血管扩张、刺激细胞因子表达、调节骨稳态和血小板聚集;病理条件下可引起结缔组织破坏和牙槽骨吸收。本文就一氧化氮在牙周炎进展中的作用机制及相关应用进行综述,以期为未来牙周疾病的治疗提供参考。

关键词: 一氧化氮, 一氧化氮合酶, 牙周组织, 牙周炎

Abstract:

Nitric oxide is a small-molecule free radical with a short half-life, which can penetrate the cell membrane and play the role of intercellular signaling. It has been found that nitric oxide plays a dual role in periodontal tissues. Under physiological conditions, it promotes vasodilation, stimulates cytokine expression, regulate bone homeostasis and platelet aggregation; under pathological conditions, it can cause connective tissue destruction and alveolar bone resorption. This article reviews the mechanism of nitric oxide in periodontitis and related application, hoping to providing reference for the future treatment of periodontal diseases.

Key words: nitric oxide, nitric oxide synthase, periodontal tissue, periodontitis

中图分类号:

R781.4

曲尼色珍, 周延民. 一氧化氮在牙周炎进展中的作用机制与应用[J]. 口腔医学, 2023, 43(10): 935-938.

QUNI Sezhen, ZHOU Yanmin. The mechanism and application of nitric oxide in the progression of periodontitis[J]. Stomatology, 2023, 43(10): 935-938.

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