富血小板纤维蛋白用于牙髓坏死的年轻恒牙患儿血管再生情况的随访分析

doi:10.13591/j.cnki.kqyx.2025.03.003

摘要/Abstract

摘要：

目的探讨注射型富血小板纤维蛋白(injectable platelet-rich fibrin,i-PRF)作为支架用于年轻恒牙牙髓坏死患儿牙髓再生术的疗效。方法纳入2021年3月至2022年10月我院口腔科收治的行牙髓再生术的年轻恒牙牙髓坏死患儿60例,根据治疗过程中使用的支架材料不同分为i-PRF组(33例)和血凝块组(27例),随访1年,采用锥形束CT(CBCT)分别于治疗前,治疗3、6、9、12个月测量患牙根尖孔直径、牙本质壁厚度、牙根长度、根管区域面积及牙根区域面积。对比两组患者临床资料,治疗前后牙根长度增加比、牙本质壁厚度增加比、根尖孔直径减小比、牙根区域面积增加比、根管区域面积减少比;记录两组患者治疗前后牙齿色泽、牙髓活力、牙齿萌出高度。结果在术后9、12个月随访时i-PRF组患牙牙根长度、牙本质壁厚度、牙根区域面积高于血凝块组(P<0.05);根据末次随访结果计算得出i-PRF组牙根长度增加比、牙本质壁厚度增加比、牙根区域面积增加比均高于血凝块组,差异具有统计学意义(P<0.05);两组患者牙齿色泽变化、牙髓活力阳性比、萌出高度比较无统计学差异(P>0.05)。结论使用血凝块和i-PRF作为支架进行牙髓再生术均能有效治疗年轻恒牙牙髓坏死,但使用i-PRF作为支架更能够促进牙根增长和牙本质壁厚度增加。

关键词: 富血小板纤维蛋白, 年轻恒牙, 牙髓坏死, 牙髓再生术

Abstract:

Objective To explore the therapeutic effect of injectable plateletrich fibrin(i-PRF) as a scaffold for pulp regeneration surgery in young permanent teeth with pulp necrosis. Methods Sixty young children with permanent tooth pulp necrosis who underwent pulp regeneration surgery in the Department of Stomatology of our hospital from March 2021 to October 2022 were included. The differentiation between the i-PRF group(33 cases)and the blood clot group(27 cases) was based on the different scaffold materials used during the treatment process. Follow up for 1 year, cone beam CT(CBCT) was used to measure the apical foramen diameter, dentin wall thickness, root length, root canal area, and root area of the affected tooth before treatment, at 3, 6, 9 and 12 months of treatment. The increase in root length, increase in dentin wall thickness, decrease in apical foramen diameter, increase in root area, decrease in root canal area, and clinical data between the two groups of patients before and after treatment were compared. The tooth color, pulp vitality, and tooth eruption height of two groups of patients were recorded before and after treatment. Results At 9 and 12 months post surgery follow-up, the root length, dentin wall thickness, and root area of the i-PRF group were higher than those of the blood clot group(P<0.05). According to the results of the last follow-up, it was calculated that the increase in root length, dentin wall thickness, and root area in the i-PRF group were higher than those in the blood clot group, and the differences were statistically significant(P<0.05). There was no statistically significant difference in the changes in tooth color, positive pulp vitality, and eruption height between the two groups of patients(P>0.05). Conclusion The use of blood clots and i-PRF as scaffolds for pulp regeneration in the treatment of young permanent tooth pulp necrosis has been proven to be effective, but the use of i-PRF as a scaffold is more effective in promoting root growth and increasing dentin wall thickness.

Key words: platelet rich fibrin, young permanent tooth, pulp necrosis, pulp regeneration surgery

中图分类号:

R781.05

买布拜木·买买提依明, 玛衣努尔·艾赛提, 帕吾孜叶·帕尔哈提, 日孜瓦古力·阿木提. 富血小板纤维蛋白用于牙髓坏死的年轻恒牙患儿血管再生情况的随访分析[J]. 口腔医学, 2025, 45(3): 175-179.

Maibubaimu MAIMAITIYIMING, Mayinuer AISAITI, Pawuziye PAERHATI, Riziwaguli AMUTI. Follow-up analysis of blood vessel regeneration in young permanent teeth of patients with pulp necrosis using platelet-rich fibrin[J]. Stomatology, 2025, 45(3): 175-179.

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