颞下颌关节骨关节炎中髁突骨软骨修复再生策略的研究进展

doi:10.13591/j.cnki.kqyx.2026.04.014

摘要/Abstract

摘要：

颞下颌关节骨关节炎(temporomandibular joint osteoarthritis,TMJOA)患者常因髁突骨质降解而引发肌肉疼痛、张口受限及下颌运动障碍。目前临床上TMJOA的常用治疗方法主要目的在于减轻患者的临床症状,但无法实现损伤组织的修复再生。本文就目前关于髁突骨软骨修复再生策略的研究进展进行总结,并展望了可促进髁突组织再生的新方向,以期为TMJOA治疗方法的进一步研究和临床应用提供理论依据和指导。

关键词: 颞下颌关节, 骨关节炎, 骨软骨缺损, 组织再生

Abstract:

Patients with temporomandibular joint osteoarthritis (TMJOA) often suffer from muscle pain, restricted mouth opening, and impaired jaw movement due to bone degeneration of the condyle. Currently, the clinical treatment for TMJOA patients mainly focuses on alleviating the patient’s clinical symptoms, but cannot achieve the repair and regeneration of damaged tissues. In this paper, the current research progress of strategies for repairing and regenerating the condylar osteochondral is reviewed, and new research directions for promoting condylar tissue regeneration are looked into, in order to provide theoretical basis and guidance for further research and clinical application of TMJOA.

Key words: temporomandibular joint, osteoarthritis, osteochondral defect, tissue regeneration

中图分类号:

R783.1

陈佳懿, 王颖, 章燕珍. 颞下颌关节骨关节炎中髁突骨软骨修复再生策略的研究进展[J]. 口腔医学, 2026, 46(4): 315-320.

CHEN Jiayi, WANG Ying, ZHANG Yanzhen. Research progress of strategies for repairing and regenerating the condylar osteochondral of temporomandibular joint osteoarthritis[J]. Stomatology, 2026, 46(4): 315-320.

图/表 1

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作者(发表时间)	研究对象	种子细胞	支架材料	生物活性因子
Zhu等^[40](2011年)	山羊	骨髓间充质干细胞	聚乳酸-羟基乙酸共聚物	神经源性表皮生长因子样分子-1
Zhu等^[41](2014年)	兔	骨髓间充质干细胞	聚乳酸-羟基乙酸共聚物	结缔组织生长因子
Wang等^[42](2021年)	兔	骨髓间充质干细胞	透明质酸/Ⅰ型胶原混合水凝胶和BCP陶瓷双层支架	-
Cheng等^[43](2021年)	兔	骨髓间充质干细胞	胶原蛋白	缺氧诱导因子-1α
Yu等^[44](2021年)	山羊	骨髓间充质干细胞	聚乙二醇-聚-(L-谷氨酸)-聚己内酯共聚物	-
Yang等^[33](2022年)	大鼠	骨髓间充质干细胞	明胶甲基丙烯酰水凝胶	转化生长因子-β
张广德等^[45](2018年)	兔	脂肪干细胞	复合水凝胶	肝细胞生长因子
郭延伟等^[35](2018年)	兔	脂肪干细胞	复合成骨多肽-透明质酸-硫酸软骨素支架	转化生长因子-β3
Sumarta等^[34](2021年)	大鼠	人脐带间充质干细胞	富血小板纤维蛋白膜	-
Ma等^[46](2024年)	大鼠	牙髓干细胞	活性氧反应性水凝胶	-