骨免疫微环境在种植体骨结合中的作用

doi:10.13591/j.cnki.kqyx.2022.12.011

摘要/Abstract

摘要： 种植体骨结合是多细胞多因子参与的动态过程,种植体-骨结合界面的成骨、破骨反应一直是口腔种植学领域的重要关注点。随着骨免疫学的发展,研究发现骨的免疫微环境在骨结合的建立和长期维持中发挥了重要作用。一系列免疫细胞通过趋化因子、细胞因子调控种植体周骨组织的修复,良好的免疫微环境可以促进组织的愈合和再生,达到更理想的骨结合效果。如何通过骨免疫调节种植体骨结合治疗种植体周炎,在口腔种植学的研究中逐渐受到关注。该文就种植体骨结合形成中的免疫应答过程作一综述。目前研究巨噬细胞的文献较多,而对其他免疫应答细胞的阐述较少,免疫细胞与种植体之间的应答反应机制仍有很多问题尚待阐明。

关键词: 骨免疫, 骨结合, 种植体, 巨噬细胞, 免疫调节

Abstract: Osseointegration of implants is a dynamic process involving multi-cell and multi-factor. Traditional research has been focusing on bone formation and absorption in osseointegration. With the development of osteoimmunology, studies find that the immune microenvironment of bone plays an important role in the establishment and long-term maintenance of osseointegration. Immune cells regulate bone repair around implants by chemokines and cytokines. Ideal immune microenvironment could promote tissue healing and regeneration to achieve better bone-implant contact. More attention has been given to the regulation of osseointegration and treatment of peri-implantitis via bone immunomodulation. In this article, the immune response process around dental implants was summarized by reviewing relevant literature. At present, there are more studies on macrophages, but few on other immune response cells. There are still many questions about the mechanism of immune response between immune cells and implants remaining to be explained.

Key words: osteoimmunology, osseointegration, implant, macrophage, immunomodulation

中图分类号:

R783.4

袁影, 黄天宇, 王浩辰, 宫苹, 向琳. 骨免疫微环境在种植体骨结合中的作用[J]. 口腔医学, 2022, 42(12): 1109-1112.

YUAN Ying, HUANG Tianyu, WANG Haochen, GONG Ping, XIANG Lin. The role of bone immune microenvironment in implant osseointegration[J]. Stomatology, 2022, 42(12): 1109-1112.

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