外泌体在骨髓间充质干细胞骨向分化及其在牙周再生中的研究进展

doi:10.13591/j.cnki.kqyx.2022.08.013

Abstract

Abstract: Exosomes are nano vesicles secreted by a variety of cells under physiological or pathological conditions. Rich in bioactive substances such as protein, nucleic acid and lipid, they are an important medium for information exchange and material transfer between cells. Studies have confirmed that exosomes can regulate the proliferation and differentiation of stem cells through proteins and miRNAs, and play an important regulatory role in the process of immune response and inflammatory response. This paper reviews the biological properties of exosomes from different cell sources in inflammatory environment and their role in osteogenic differentiation, so as to provide reference for the treatment of bone defect caused by periodontitis.

Key words: exosome, bone marrow mesenchymal stem cell, osteogenic differentiation, periodontitis, inflammation

CLC Number:

R781.4

ZHANG Shuting, WU Yaxing, LIU Cuicui, LI Chenchen, ZHANG Jing. Research progress of exosomes in osteogenic differentiation of bone marrow mesenchymal stem cells and in periodontal regeneration[J]. Stomatology, 2022, 42(8): 741-744.

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Research progress of exosomes in osteogenic differentiation of bone marrow mesenchymal stem cells and in periodontal regeneration

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