药物性牙龈肥大发病机制的研究进展

doi:10.13591/j.cnki.kqyx.2022.06.012

Abstract

Abstract: Drug-induced gingival overgrowth(DIGO)is mainly caused by long-term use of phenytoin sodium, cyclosporine A, and nifedipine . It not only affects the cleanliness and aesthetics of dental surface and the normal physiological function of teeth, but may also cause psychological disorders in patients. However, the pathogenesis of DIGO is complex and remains unclear, making treatment more difficult. Many scholars have studied it from various aspects and put forward many ideas and hypotheses, including the mechanism of collagen production and degradation imbalance, inflammation and so on. This article summarizes research on the pathogenesis of DIGO in recent years from aspects of both molecular mechanism and specific mechanism of drugs, and discusses the future research direction of DIGO, hoping to help the prevention and clinical treatment of DIGO.

Key words: drug-induced gingival overgrowth, collagen, inflammation, phenytoin, cyclosporin A, nifedipine

CLC Number:

R781.4

LI Peitong, WANG Shuangcheng, LIU Zhen, WANG Jun. Advances in studies on pathogenesis of drug-induced gingival overgrowth[J]. Stomatology, 2022, 42(6): 545-550.

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Advances in studies on pathogenesis of drug-induced gingival overgrowth

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