m6A甲基化修饰参与成骨分化调控的研究进展

doi:10.13591/j.cnki.kqyx.2022.07.016

Abstract

Abstract: N⁶-methyladenosine (m⁶A) is the most abundant epigenetic modification in eukaryotes and plays a significant regulatory role in mammalian growth and disease control. Studies have found that m⁶A modification can accurately regulate the gene expression related to bone remodeling and development no matter in a physiological or pathological state, thus affecting bone metabolism balance. In this systematic review, we summarized regulatory mechanisms of m⁶A modification in osteogenic differentiation, in order to provide new ideas and potential targets for promoting bone formation and preventing or treating diseases related to bone metabolism.

Key words: m⁶A modification, RNA methylation, osteogenic differentiation, regulatory mechanism

CLC Number:

ZHANG Xiaochen, SUN Weifu, FANG Shishu, QIN Wen, JIN Zuolin. Research progress of N⁶-methyladenosine in regulating osteogenic differentiation[J]. Stomatology, 2022, 42(7): 655-658.

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Research progress of N⁶-methyladenosine in regulating osteogenic differentiation

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Research progress of N6-methyladenosine in regulating osteogenic differentiation

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Research progress of N⁶-methyladenosine in regulating osteogenic differentiation