口腔扁平苔藓合并2型糖尿病的临床及病理特征研究

doi:10.13591/j.cnki.kqyx.2022.09.007

Abstract

Abstract: Objective To analyze the clinical and histopathological characteristics of oral lichen planus (OLP) complicated with type 2 diabetes mellitus (T2DM) through case-control study. Methods One hundred and four patients were divided into OLP group and OLP+T2DM group and their basic information, clinical types and REU scores of OLP were collected. Histopathological manifestations were described by two pathologists. Clinical and histopathological manifestations between the two groups were analyzed by SPSS 24.0. Results The prevalence of erosive OLP and REU score in OLP+T2DM group were significantly higher than those in OLP group (P＜0.001). After one month follow-up, REU score of OLP patients taking hypoglycemic drugs decreased significantly (P＜0.001), and that of OLP patients with ideal blood glucose control (P＜0.01) decreased significantly. Logistic regression analysis showed that: high REU score, erosion type, dense lymphocyte infiltration, unclear lymphocyte infiltration zone, severe inflammation in the basal layer, and presence of fibrin in the basal layer (OR=1.58, 37.15, 8.49, 10.16, 3.94, 4.35) were typical characteristics of OLP with T2DM. Conclusion OLP patients with T2DM have more severe clinical lesions and higher degree of tissue destruction. A personalized plan should be made to obtain better treatment effect.

Key words: oral lichen planus, type 2 diabetes mellitus, case-control study, clinical characteristic, histopathology

CLC Number:

R781.59

LI Kaiyi, HE Wenxiu, REN Xiaomeng, LUO Haiyan, LI Chunlei, HUA Hong. Clinical and histopathological characteristics of oral lichen planus patients with type 2 diabetes mellitus[J]. Stomatology, 2022, 42(9): 802-806.

References

[1] Alrashdan MS, Cirillo N, McCullough M. Oral lichen planus:A literature review and update[J]. Arch Dermatol Res, 2016, 308(8):539-551.
[2] Mutafchieva MZ, Draganova-Filipova MN, Zagorchev PI, et al. Oral lichen planus-known and unknown:A review[J]. Folia Med (Plovdiv), 2018, 60(4):528-535.
[3] Kim DL, Kim SD, Kim SK, et al. Is an oral glucose tolerance test still valid for diagnosing diabetes mellitus?[J]. Diabetes Metab J, 2016, 40(2):118-128.
[4] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版)[J]. 中华内分泌代谢杂志, 2021, 37(4):311-398.
[5] Wu CZ, Yuan YH, Liu HH, et al. Epidemiologic relationship between periodontitis and type 2 diabetes mellitus[J]. BMC Oral Health, 2020, 20(1):204.
[6] Liu T, Wei Y, Zhu YN, et al. Caries status and salivary alterations of type-1 diabetes mellitus in children and adolescents:A systematic review and meta-analysis[J]. J Evid Based Dent Pract, 2021, 21(1):101496.
[7] Martorano-Fernandes L, Dornelas-Figueira LM, Marcello-Machado RM, et al. Oral candidiasis and denture stomatitis in diabetic patients:Systematic review and meta-analysis[J]. Braz Oral Res, 2020, 34:e113.
[8] Otero Rey EM, Yáñez-Busto A, Rosa Henriques IF, et al. Lichen planus and diabetes mellitus:Systematic review and meta-analysis[J]. Oral Dis, 2019, 25(5):1253-1264.
[9] Hamrah MH, Baghalian A, Ghadimi S, et al. The prevalence and correlates of fissured tongue among outpatients in andkhoy city, Afghanistan:A cross-sectional study[J]. Clin Cosmet Investig Dent, 2021, 13:335-342.
[10] Ramos-Garcia P, Roca-Rodriguez M, Aguilar-Diosdado M, et al. Diabetes mellitus and oral cancer/oral potentially malignant disorders:A systematic review and meta-analysis[J]. Oral Dis, 2021, 27(3):404-421.
[11] 中华口腔医学会口腔黏膜病学专业委员会, 中华口腔医学会中西医结合专业委员会. 口腔扁平苔藓诊疗指南(修订版)[J]. 中华口腔医学杂志, 2022, 57(2):115-121.
[12] van der Meij EH, van der Waal I. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications[J]. J Oral Pathol Med, 2003, 32(9):507-512.
[13] Piboonniyom SO, Treister N, Pitiphat W, et al. Scoring system for monitoring oral lichenoid lesions:A preliminary study[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005, 99(6):696-703.
[14] World Health Organization. Oral health survey: Basic methods[M]. 4th edition. Geneva, Switzerland:World Health Organization, 1997.
[15] 张筱林, 吴奇光, 郑麟蕃. 口腔扁平苔藓的组织病理学分析[J]. 中华口腔科杂志, 1984, 19(1):9-12.
[16] Idrees M, Kujan O, Shearston K, et al. Oral lichen planus has a very low malignant transformation rate:A systematic review and meta-analysis using strict diagnostic and inclusion criteria[J]. J Oral Pathol Med, 2021, 50(3):287-298.
[17] Indurkar MS, Maurya AS, Indurkar S. Oral manifestations of diabetes[J]. Clin Diabetes, 2016, 34(1):54-57.
[18] Mallah N, Ignacio Varela-Centelles P, Seoane-Romero J, et al. Diabetes mellitus and oral lichen planus:A systematic review and meta-analysis[J]. Oral Dis, 2021:2021May29.
[19] Zhao W, Yang Y, Wu FL, et al. The reciprocal association between diabetes mellitus and erosive oral lichen planus[J]. Oral Dis, 2019, 25(4):1235-1236.
[20] Flick MJ, LaJeunesse CM, Talmage KE, et al. Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif[J]. J Clin Invest, 2007, 117(11):3224-3235.

Clinical and histopathological characteristics of oral lichen planus patients with type 2 diabetes mellitus

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[4]	. Meta-analysis and systematic evaluation of the efficacy of combined total glucosides of paeony capsules in the treatment of oral lichen planus [J]. , 2019, 39(6): 523-529.
[5]	Xu -Zheng shan lingGan. Research progress on the metabolism of patients with type 2 diabetes mellitus via periodontal non-surgical treatment. [J]. , 2019, 39(2): 183-187.
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[7]	. Research on the present situation of interplay of type 2 diabetes mellitus, chronic periodontitis and non-surgical periodontal treatment [J]. , 2018, 38(9): 839-843.
[8]	. CCR6 -CCL20 expression profile in peripheral blood and tissue of Oral Lichen Planus [J]. , 2018, 38(5): 406-409.
[9]	. Effects of diode laser on the treatment for chronic periodontitis patients with type 2 diabetes mellitus [J]. , 2018, 38(3): 237-240.
[10]	. Expression of KLF-6 in the patients with oral lichen planus canceration [J]. , 2018, 38(2): 132-134.
[11]	. Study on the immunoregulation mechanism of Astragalus Polysaccharide in oral lichen planus [J]. , 2017, 37(7): 593-597.
[12]	. The influence of type 2 diabetic rats with periodontitis on histological changes in periodontal tissue and serum levels of TNF-α, IL-6 and PAI-1 [J]. , 2017, 37(10): 889-893.
[13]	. Impact of basic periodontal therapy on the peripheral blood IL-10 and TGF-β levels in oral lichen planus patients [J]. , 2017, 37(1): 53-56.
[14]	. Curative effects and security of tacrolimus on oral lichen planus：A systematic review [J]. , 2017, 37(1): 38-45.
[15]	. Observation of RANTES in various types of abnormal humour syndrome patients with oral lichen planus [J]. , 2016, 36(8): 686-688.